操纵核架构。
Manipulating nuclear architecture.
机构信息
Transcription Imaging Consortium, Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, United States.
Division of Hematology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States.
出版信息
Curr Opin Genet Dev. 2014 Apr;25:1-7. doi: 10.1016/j.gde.2013.10.014. Epub 2013 Dec 12.
Abstract
The eukaryotic genome is highly organized in the nucleus. Genes can be localized to specific nuclear compartments in a manner reflecting their activity. A plethora of recent reports has described multiple levels of chromosomal folding that can be related to gene-specific expression states. Here we discuss studies designed to probe the causal impact of genome organization on gene expression. The picture that emerges is that of a reciprocal relationship in which nuclear organization is not only shaped by gene expression states but also directly influences them.
摘要
真核生物基因组在细胞核中高度组织化。基因可以以反映其活性的方式定位于特定的核区室。最近有大量报道描述了可与基因特异性表达状态相关的多种染色体折叠水平。在这里，我们讨论了旨在探讨基因组组织对基因表达的因果影响的研究。出现的情况是，核组织不仅受到基因表达状态的影响，而且直接影响基因表达状态，两者之间存在一种相互关系。
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