Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine; Research Institute of Endocrinology, Kyung Hee University, Seoul, Korea.
Diabetes Metab J. 2011 Apr;35(2):107-16. doi: 10.4093/dmj.2011.35.2.107. Epub 2011 Apr 30.
Hyperglycemia that does not satisfy the diagnostic criteria for diabetes mellitus (DM) is generally called prediabetes (preDM). The global prevalence of preDM has been increasing progressively in the past few decades, and it has been established that preDM status is a strong risk factor for DM and cardiovascular disease. Currently, preDM status is classified into two subtypes: impaired fasting glucose and impaired glucose tolerance. Currently, preDM is not regarded as an independent clinical entity, but only as a risk factor for others. In this article, we review various clinical aspects of preDM in terms of the working definition, changes in criteria over the years, epidemiology, and pathophysiological characteristics, and its clinical significance in current medicine.
高血糖但不符合糖尿病（DM）的诊断标准通常被称为糖尿病前期（preDM）。在过去几十年中，全球 preDM 的患病率一直在逐步增加，并且已经证实 preDM 状态是 DM 和心血管疾病的强烈危险因素。目前，preDM 状态分为两种亚型：空腹血糖受损和葡萄糖耐量受损。目前，preDM 不被视为独立的临床实体，而仅被视为其他疾病的危险因素。在本文中，我们根据工作定义、多年来标准的变化、流行病学和病理生理学特征以及其在当前医学中的临床意义，综述了 preDM 的各种临床方面。
