Kijan Christina, Hugen Sanne, Thomas Rachel E, Oberbauer Anita M, Leegwater Peter A J, Fieten Hille, German Alexander J, Mandigers Paul J J
Expertise Centre Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.
Animals (Basel). 2023 May 3;13(9):1532. doi: 10.3390/ani13091532.
Gastric carcinoma is generally considered to be a rare disease in dogs, carrying a grave prognosis. However, in the Tervueren and Groenendael varieties of the Belgian Shepherd dog breed, the disease is highly prevalent. While histopathology is the gold standard for diagnosing gastric carcinoma, there is no general consensus on the methods for histological classification in these cases. Biopsies of a group of 61 dogs with confirmed gastric carcinoma (45 Tervueren and 16 Groenendael) were examined and classified according to World Health Organization (WHO) and Laurén classifications. Kaplan-Meier curves were used to compare survival between the different subtypes and simple and multiple linear regression were used to analyse the association between age of onset and breed variant, sex, neuter status, location of the tumour, inflammation score, and Laurén and WHO classifications. Mean age at diagnosis was significantly different in Groenendael (10.1 ± 2.01) and Tervueren dogs (8.5 ± 1.90). The Laurén classification resulted in 29 (48%) diffuse- and 32 (52%) intestinal-type tumours. Applying the WHO classification resulted in 30 (49%) tubular carcinoma growth patterns and 31 (51%) others. Median survival time was significantly reduced for the diffuse type as compared to the intestinal type according to the Laurén classification, with the same median survival time results for tubular compared to non-tubular subtypes according to the WHO classification (median survival time of 61 vs. 182 days, respectively). Using the WHO and Lauren classification on tumour biopsies may help the practising clinician in the prognostication of gastric carcinoma in Tervueren and Groenendael dogs.
胃癌通常被认为是犬类中的罕见疾病，预后严重。然而，在比利时牧羊犬品种的特弗伦犬和格罗安达犬中，这种疾病非常普遍。虽然组织病理学是诊断胃癌的金标准，但在这些病例的组织学分类方法上尚无普遍共识。对一组61只确诊为胃癌的犬（45只特弗伦犬和16只格罗安达犬）的活检样本进行了检查，并根据世界卫生组织（WHO）和劳伦分类法进行了分类。采用Kaplan-Meier曲线比较不同亚型之间的生存率，并采用简单和多元线性回归分析发病年龄与品种变异、性别、绝育状态、肿瘤位置、炎症评分以及劳伦和WHO分类之间的关联。格罗安达犬（10.1±2.01）和特弗伦犬（8.5±1.90）的诊断平均年龄有显著差异。劳伦分类法得出29例（48%）弥漫型和32例（52%）肠型肿瘤。应用WHO分类法得出30例（49%）管状癌生长模式和31例（51%）其他模式。根据劳伦分类法，弥漫型的中位生存时间明显低于肠型，根据WHO分类法，管状亚型与非管状亚型的中位生存时间结果相同（中位生存时间分别为61天和182天）。对肿瘤活检样本使用WHO和劳伦分类法可能有助于执业临床医生对特弗伦犬和格罗安达犬的胃癌进行预后评估。
