Ottinetti A, Sapino A
Dipartimento di Scienze Biomediche ed Oncologia Umana, Università di Torino, Italia.
Breast Cancer Res Treat. 1988 Jul;11(3):241-8. doi: 10.1007/BF01807282.
Size and density of microvessels in close proximity to normal, hyperplastic, and in situ neoplastic mammary epithelium were evaluated with a morphometric method. Human tissue samples were obtained from breast mammoplasty or biopsy specimens with diagnosis of either epitheliosis or ductal carcinoma in situ. The mean vessel size was significantly enhanced in hyperplastic and neoplastic lesions as compared to mammoplasty specimens considered as 'normal'. On the contrary, the density of the microvessels around the epithelium was comparable in the three groups of tissues. It appears that as long as the basement membrane remains intact, sprouting of new vessels around neoplastic lesions is not manifested.
采用形态测量法评估了紧邻正常、增生及原位肿瘤性乳腺上皮的微血管大小和密度。人体组织样本取自乳房整形手术或活检标本，诊断为上皮增生或原位导管癌。与被视为“正常”的乳房整形标本相比，增生性和肿瘤性病变中的平均血管大小显著增加。相反，三组组织中上皮周围微血管的密度相当。似乎只要基底膜保持完整，肿瘤性病变周围新血管的萌发就不会表现出来。
