Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Thorax. 2014 Dec;69(12):1149-51. doi: 10.1136/thoraxjnl-2014-205249. Epub 2014 Mar 3.
Access to medications for chronic disease management is limited in many low and middle-income countries (LMICs), resulting in suboptimal care and avoidable morbidity and mortality. We performed a survey of COPD and asthma medicines that appeared on the national essential medicines lists (NEMLs) of 32 LMICs. Nearly all countries (>90%) had assigned essential medicines for treatment of exacerbations and early stable disease stages, but not for steps 4 (22%) and 5 (6%) controlled asthma management. The number of treatment options was limited, with long-acting β2-agonists (LABA) and combination dosage forms being notably absent. Suboptimal availability of chronic respiratory disease medicines suggests that implementation of NEMLs is the main problem in clinical practice.
在许多中低收入国家(LMICs),慢性病管理药物的可及性受到限制,导致护理效果不佳,发病率和死亡率居高不下。我们对 32 个 LMICs 的国家基本药物清单(NEMLs)中出现的 COPD 和哮喘药物进行了调查。几乎所有国家(>90%)都为治疗恶化和早期稳定期疾病阶段分配了基本药物,但没有为第 4 步(22%)和第 5 步(6%)控制哮喘管理分配药物。治疗选择的数量有限,长效β2-激动剂(LABA)和联合剂型明显缺失。慢性呼吸道疾病药物的供应不足表明,NEMLs 的实施是临床实践中的主要问题。