Division of Gastroenterology, Department of Medicine, and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Division of Gastroenterology, Department of Medicine, and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Opin Immunol. 2014 Apr;27:75-82. doi: 10.1016/j.coi.2014.01.013. Epub 2014 Mar 3.
Innate lymphoid cells (ILCs) are a group of lymphocytes that promote rapid cytokine-dependent innate immunity, inflammation and tissue repair. In addition, a growing body of evidence suggests ILCs can influence adaptive immune cell responses. During fetal development a subset of ILCs orchestrate the generation and maturation of secondary lymphoid tissues. Following birth, ILCs continue to modulate adaptive immune cell responses indirectly through interactions with stromal cells in lymphoid tissues and epithelial cells at barrier surfaces. In this review we summarize the current understanding of how ILCs modulate the magnitude and quality of adaptive immune cell responses, and in particular focus on recent evidence suggesting that ILCs can also directly regulate CD4(+) T cells. Further, we discuss the implications that these pathways may have on human health and disease.
先天淋巴细胞 (ILC) 是一群促进快速细胞因子依赖的固有免疫、炎症和组织修复的淋巴细胞。此外，越来越多的证据表明 ILC 可以影响适应性免疫细胞反应。在胎儿发育过程中，一组 ILC 协调次级淋巴组织的生成和成熟。出生后，ILC 通过与淋巴组织中的基质细胞和屏障表面的上皮细胞相互作用，继续间接调节适应性免疫细胞反应。在这篇综述中，我们总结了目前对 ILC 如何调节适应性免疫细胞反应的幅度和质量的理解，特别是重点关注最近的证据表明 ILC 也可以直接调节 CD4(+)T 细胞。此外，我们还讨论了这些途径可能对人类健康和疾病的影响。
