Mao Xudong, Zheng Hongchao, Liu Zhiwen, Wu Yan, Na Risu, Wang Chunping, Zheng Xulei, Gao Jing, Wu Liming, Shi Xiaohong, Liu Cong, Sheng Hongguang
Department of Endocrinology, Xuhui District Central Hospital, Shanghai, China.
Department of Cardiology, Xuhui District Central Hospital, Shanghai, China.
PLoS One. 2014 Mar 5;9(3):e90729. doi: 10.1371/journal.pone.0090729. eCollection 2014.
To find an association between basic characteristics, seasons as well as disease types and 25-Hydroxyvitamin D serum concentrations in Chinese patients.
We randomly selected 5470 Chinese patients with various diseases, who were hospitalized between May 2012 and August 2013 in Shanghai and analyzed their serum 25-Hydroxyvitamin D2 (25 (OH)D2) and 25-Hydroxyvitamin D3 (25(OH)D3) concentrations with liquid chromatography-tandem mass spectrometry (LC-MS/MS) as well as their parathyroid hormone (PTH) and serum creatinine blood levels. The resulting data were analyzed by linear regression and variance analyses or multivariate analysis with covariance.
The 25(OH)D serum concentrations were lowest in December. Among the subjects with a median age of 83.0 ± 16.0, the median 25(OH)D2, 25(OH)D3 and total 25(OH)D serum concentrations were 1.00 ± 1.80 ng/ml, 12.20 ± 8.50 ng/ml and 14.80 ± 9.80 respectively, indicating a prevalent 25(OH)D deficiency. According to our multivariate analysis of covariance, the factors affecting 25(OH)D2 and 25(OH)D3 serum concentrations included age, creatinine, PTH, season and type of disease, whereas gender correlated only with 25(OH)D2 and 25(OH)D2 and D3 values correlated negatively with each other. Our results further revealed that 25(OH)D3 levels were low while 25(OH)D2 levels were high among patients with lung diseases, dyskinesia and coronary heart diseases. In addition, participants with diabetes and cerebral infarction had higher 25(OH)D3 serum concentrations compared with lung disease patients.
Vitamin D intake particularly during winter and summer seasons is important especially for elderly lung disease, dyskinesia and coronary heart disease patients to improve their quality of life.
探寻中国患者的基本特征、季节以及疾病类型与血清25-羟基维生素D浓度之间的关联。
我们随机选取了5470例患有各种疾病的中国患者，这些患者于2012年5月至2013年8月期间在上海住院治疗。我们采用液相色谱-串联质谱法（LC-MS/MS）分析了他们血清中的25-羟基维生素D2（25(OH)D2）和25-羟基维生素D3（25(OH)D3）浓度，以及甲状旁腺激素（PTH）和血清肌酐水平。所得数据通过线性回归、方差分析或协方差多元分析进行分析。
12月时血清25(OH)D浓度最低。在中位年龄为83.0±16.0岁的受试者中，血清25(OH)D2、25(OH)D3和总25(OH)D的中位浓度分别为1.00±1.80纳克/毫升、12.20±8.50纳克/毫升和14.80±9.80纳克/毫升，表明普遍存在25(OH)D缺乏。根据我们的协方差多元分析，影响25(OH)D2和25(OH)D3血清浓度的因素包括年龄、肌酐、PTH、季节和疾病类型，而性别仅与25(OH)D2相关，且25(OH)D2和25(OH)D3值呈负相关。我们的结果进一步显示，患有肺部疾病、运动障碍和冠心病的患者25(OH)D3水平较低，而25(OH)D2水平较高。此外，与肺部疾病患者相比，患有糖尿病和脑梗死的参与者血清25(OH)D3浓度更高。
尤其是在冬季和夏季，补充维生素D对改善老年肺部疾病、运动障碍和冠心病患者的生活质量尤为重要。
