Bolleku Eriola, Idrizi Alma, Barbullushi Myftar, Bajrami Valbona, Likaj Ermal, Thereska Nestor, Ohri Ilir, Nunci Lordian
Service of Nephrology, UHC "Mother Teresa", Tirana, Albania.
Service of Cardiosurgery, UHC "Mother Teresa", Tirana, Albania.
Med Arch. 2013;67(5):381-2. doi: 10.5455/medarh.2013.67.381-382.
Lactic acidosis is a rare but severe complication in patients with type 2 diabetes treated with metformin. Patients with lactic acidosis show commonly signs of shock, tissue hypoxia, acute hepatic or renal failure and the link between metformin therapy and lactic acidosis may be coincidental, associated or causal. Excessive plasma metformin concentrations show that lactic acidosis is due to a toxicological mechanism. We report a case of severe multiorganic failure in a subject after treatment with high doses of metformin.
乳酸酸中毒是接受二甲双胍治疗的2型糖尿病患者中一种罕见但严重的并发症。乳酸酸中毒患者通常表现出休克、组织缺氧、急性肝或肾衰竭的症状，二甲双胍治疗与乳酸酸中毒之间的联系可能是巧合、相关或因果关系。血浆二甲双胍浓度过高表明乳酸酸中毒是由毒理学机制引起的。我们报告一例在大剂量服用二甲双胍治疗后出现严重多器官功能衰竭的病例。
