Safadi R, Dranitzki-Elhalel M, Popovtzer M, Ben-Yehuda A
Division of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Am J Nephrol. 1996;16(6):520-2. doi: 10.1159/000169052.
A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis. There was a discrepancy between the patient's elevated serum creatinine level, indicative of severe renal insufficiency, and her very low blood urea nitrogen content. It is postulated that the patient's extremely severe acidosis interfered with her hepatic urea generation, contributing to this unusual biochemical abnormality.
一名69岁患有弥漫性动脉粥样硬化的糖尿病女性，因造影剂肾病和严重的二甲双胍诱导的乳酸性酸中毒出现急性肾衰竭。患者血清肌酐水平升高表明存在严重肾功能不全，但其血尿素氮含量却非常低，两者存在差异。据推测，患者极其严重的酸中毒干扰了肝脏尿素生成，导致了这种不寻常的生化异常。
