Carillon Julie, Rugale Caroline, Rouanet Jean-Max, Cristol Jean-Paul, Lacan Dominique, Jover Bernard
UMR 204 - Prévention des Malnutritions et des Pathologies Associées, Université Montpellier 2 , Montpellier , France .
Int J Food Sci Nutr. 2014 Aug;65(5):602-9. doi: 10.3109/09637486.2014.893286. Epub 2014 Mar 6.
We assessed the influence of SODB, a melon superoxide dismutase (SOD), on left ventricular (LV) hypertrophy in SHR. SODB (4 or 40U SOD) was given orally for 4 or 28 days to SHR. For each treatment period, LV weight index (LVWI) and cardiomyocytes size were measured. SOD, glutathione peroxidase (GPx) and catalase expressions, and LV production and presence of superoxide anion were determined. Pro-inflammatory markers were also measured. SODB reduced LVWI and cardiomyocytes size after 4 or 28 days. Cardiac SOD and GPx increased by 30-40% with SODB. The presence but not production of superoxide anion was significantly reduced by SODB. No effect of SODB was detected on inflammatory status in any group. The beneficial effect of SODB on cardiac hypertrophy seems to be related to the stimulation of endogenous antioxidant defense, suggesting that SODB may be of interest as a dietary supplementation during conventional antihypertensive therapy.
我们评估了甜瓜超氧化物歧化酶（SOD）——SODB对自发性高血压大鼠（SHR）左心室肥厚的影响。将SODB（4或40单位超氧化物歧化酶）口服给予SHR 4天或28天。在每个治疗期，测量左心室重量指数（LVWI）和心肌细胞大小。测定超氧化物歧化酶、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶的表达，以及左心室超氧阴离子的产生和存在情况。还测量了促炎标志物。4天或28天后，SODB降低了LVWI和心肌细胞大小。SODB使心脏超氧化物歧化酶和GPx增加了30%-40%。SODB显著降低了超氧阴离子的存在，但未降低其产生。在任何组中均未检测到SODB对炎症状态有影响。SODB对心脏肥大的有益作用似乎与内源性抗氧化防御的刺激有关，这表明在传统抗高血压治疗期间，SODB作为膳食补充剂可能是有益的。
