Nutrition & Métabolisme, UMR 204 NutriPass - Prévention des Malnutritions et des Pathologies Associées, Université Montpellier Sud de France, Montpellier, France; Bionov Sarl, Avignon, France.
Mol Nutr Food Res. 2014 Apr;58(4):842-50. doi: 10.1002/mnfr.201300466. Epub 2013 Nov 20.
Obesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue.
We evaluated the effects of a 1-month curative supplementation with SODB on the adipose tissue of obese hamsters. Animals received either a standard diet or a cafeteria diet for 15 wk. Cafeteria diet induced obesity and related disorders, including insulin resistance and oxidative stress, in the abdominal adipose tissue. After SODB supplementation, the adipose tissue weight was decreased, probably by activating adipocytes lipolysis and thus reducing their size. SODB treatment also resulted in abdominal adipose tissue fibrosis reduction. Finally, SODB administration increased the expression of endogenous antioxidant enzymes and thus reduced oxidative stress and insulin resistance. The improvement of insulin sensitivity observed after SODB treatment could explain adipocyte lipolysis activation and fibrosis reduction.
These findings demonstrate that a dietary SOD supplementation could be a useful strategy against obesity-related modifications in adipose tissue.
肥胖相关的代谢综合征常伴随着胰岛素敏感性降低，从而导致多种变化。然而，饮食中的抗氧化剂可以预防胰岛素抵抗。我们之前已经证明了一种瓜类超氧化物歧化酶（SOD）对肥胖仓鼠的预防作用。然而，其在脂肪组织上的抗氧化作用从未被研究过。
我们评估了为期 1 个月的 SODB 治疗性补充对肥胖仓鼠脂肪组织的影响。动物接受标准饮食或自助餐厅饮食 15 周。自助餐厅饮食导致肥胖和相关疾病，包括胰岛素抵抗和氧化应激，发生在腹部脂肪组织中。SODB 补充后，脂肪组织重量减轻，可能是通过激活脂肪细胞脂解作用，从而减小其体积。SODB 治疗还导致腹部脂肪组织纤维化减少。最后，SODB 给药增加了内源性抗氧化酶的表达，从而减少了氧化应激和胰岛素抵抗。SODB 治疗后观察到的胰岛素敏感性改善可以解释脂肪细胞脂解作用的激活和纤维化的减少。
这些发现表明，饮食中 SOD 的补充可能是对抗肥胖相关脂肪组织改变的一种有效策略。
