Bertesteanu Serban, Chifiriuc Mariana Carmen, Grumezescu Alexandru Mihai, Printza Atnanasia G, Marie-Paule Thill, Grumezescu Valentina, Mihaela Vlad, Lazar Veronica, Grigore Raluca
University of Bucharest, Faculty of Biology, Microbiology Department, Ale. Portocalelor 1-3, 60101, Bucharest, Romania.
Curr Med Chem. 2014;21(29):3383-90. doi: 10.2174/0929867321666140304104328.
The emergence of antibiotic resistance in microbial strains is representing one of the major threats to public health worldwide, due to the decreased or total cancelling of the available antibiotics effectiveness, correlated with the slow development of novel antibiotics. Due to their excellent biodegradability and biocompatibility, the synthetic polymers could find a lot of biomedical applications, such as the development of biomaterials with optimized properties and of drug delivery systems. This review is focusing on the applications of synthetic, biodegradable polymers for the improvement of antiinfective therapeutic and prophylactic agents (i.e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with increased biocompatibility and resistance to microbial colonization.
微生物菌株中抗生素耐药性的出现是全球公共卫生面临的主要威胁之一，这是因为现有抗生素有效性降低或完全丧失，且新型抗生素研发进展缓慢。合成聚合物因其出色的生物降解性和生物相容性，可在许多生物医学领域得到应用，比如开发具有优化性能的生物材料和药物递送系统。本综述聚焦于合成可生物降解聚合物在提高抗感染治疗和预防药物（即抗菌、抗炎药物及疫苗）活性方面的应用，以及在设计具有更高生物相容性和抗微生物定植能力的生物材料方面的应用。
