Holban Alina Maria, Gestal Monica Cartelle, Grumezescu Alexandru Mihai
Faculty of Applied Chemistry and Materials Science, "Politehnica" University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1-7 Polizu Street, 011061 Bucharest, Romania.
Curr Med Chem. 2014;21(29):3375-82. doi: 10.2174/0929867321666140304103810.
Due to the great prevalence of persistent and recurrent implanted device associated-infections novel and alternative therapeutic approaches are intensely investigated. For reducing complications and antibiotic resistance development, one major strategy is using natural or synthetic modulators for targeting microbial molecular pathways which are not related with cell multiplication and death, as Quorum Sensing, virulence and biofilm formation. The purpose of this review paper is to discuss the most recent in vitro approaches, investigating the efficiency of some novel antimicrobial products and the nano-technologic progress performed in order to increase their effect and stability.
由于持续性和复发性植入装置相关感染的高发生率，新型和替代治疗方法正在深入研究中。为了减少并发症和抗生素耐药性的产生，一个主要策略是使用天然或合成调节剂来靶向与细胞增殖和死亡无关的微生物分子途径，如群体感应、毒力和生物膜形成。这篇综述文章的目的是讨论最新的体外方法，研究一些新型抗菌产品的效率以及为提高其效果和稳定性所取得的纳米技术进展。
