Baker B S, Powles A V, Lambert S, Valdimarsson H, Fry L
Department of Immunology, St. Mary's Hospital Medical School, London, England.
Acta Derm Venereol. 1988;68(5):430-4.
T lymphocyte and dendritic cell subpopulations were counted in untraumatized, uninvolved skin of 27 patients with psoriasis. Eight of the patients proved to be Koebner-positive, as determined by tape stripping and punch biopsy, and 19 Koebner-negative. In the epidermis the CD4/CD8 T cell ratio was significantly higher in the Koebner-positive vis-à-vis Koebner-negative patients (median CD4/CD8 = 1.68 and 0.75, respectively: p less than 0.05). This resulted from a small increase in CD4 and a larger decrease in CD8 epidermal T cells in the Koebner-positive group. However, numbers of epidermal dendritic cells did not differ significantly between the two groups. In the dermis the CD4/CD8 T cell ratio was also higher in the Koebner-positive than in Koebner-negative patients (median of 3.56 and 2.57, respectively). These findings demonstrate that the tendency of uninvolved skin of psoriatic individuals to become lesional after trauma is associated with a predominance of CD4 over CD8 T cells in the epidermis.
对27例银屑病患者未受创伤、未受累皮肤中的T淋巴细胞和树突状细胞亚群进行了计数。通过胶带剥离和打孔活检确定，其中8例患者为同形反应阳性，19例为同形反应阴性。在表皮中，同形反应阳性患者的CD4/CD8 T细胞比值显著高于同形反应阴性患者（CD4/CD8中位数分别为1.68和0.75：p<0.05）。这是由于同形反应阳性组中CD4略有增加，而CD8表皮T细胞大幅减少。然而，两组之间表皮树突状细胞的数量没有显著差异。在真皮中，同形反应阳性患者的CD4/CD8 T细胞比值也高于同形反应阴性患者（中位数分别为3.56和2.57）。这些发现表明，银屑病患者未受累皮肤在创伤后出现皮损的倾向与表皮中CD4 T细胞相对于CD8 T细胞占优势有关。
