Center for Disease Control and Prevention of Huizhou, No. 10, Fumin Road, Huizhou, 516003, Guangdong, People's Republic of China.
Arch Virol. 2014 Aug;159(8):2003-10. doi: 10.1007/s00705-014-2035-1. Epub 2014 Mar 9.
Little information is available on the etiology and prevalence of viruses other than influenza viruses causing influenza-like illnesses (ILIs) in China. This study was conducted for simultaneous detection and identification of 14 respiratory viruses in Huizhou using real-time PCR. In total, viruses were detected in 48.66 % of ILI patient samples, in which influenza virus (19.98 %) was the most commonly detected, followed by rhinovirus (7.46 %), human coronaviruses (3.63 %), human metapneumovirus (3.06 %), parainfluenza virus (3.06 %), respiratory syncytial virus (2.39 %), adenovirus (2.29 %), and human bocavirus (1.43 %). Co-infections occurred in 5.35 % of all tested specimens and 11.00 % (56/509) of infected patients. Children under 5 years and adults older than 60 years were more likely to have one or more detectable viruses associated with their ILI (OR=1.75, 95 % CI: 1.37; 2.23). Influenza virus was detected during each month of each year, and increased viral activity was observed in 2013. Infections with adenovirus and human metapneumovirus had characteristic seasonal patterns. No significant differences were found in positive the rate between the gender groups, while significantly differences in positive rate were found among the different age groups (P-value<0.001). This study confirmed that multiple respiratory viruses may circulate concurrently in the population and play an important role in the etiology of ILI. The most frequent symptoms associated with respiratory viruses were sore throat, rhinorrhea and headache. This information needs to be considered by clinicians when treating patients presenting with ILI, and it could serve as a reference for government officers when designing and implementing effective intervention plans.
在中国，除流感病毒外，其他引起流感样疾病（ILI）的病毒的病因和流行情况信息有限。本研究采用实时 PCR 法对惠州地区的 14 种呼吸道病毒进行同步检测和鉴定。共在 48.66%的 ILI 患者样本中检测到病毒，其中流感病毒（19.98%）最为常见，其次为鼻病毒（7.46%）、人冠状病毒（3.63%）、人偏肺病毒（3.06%）、副流感病毒（3.06%）、呼吸道合胞病毒（2.39%）、腺病毒（2.29%）和人博卡病毒（1.43%）。所有检测样本中有 5.35%发生了混合感染，509 例感染患者中有 11.00%（56 例）发生了混合感染。5 岁以下儿童和 60 岁以上成人更有可能同时感染一种或多种与 ILI 相关的病毒（OR=1.75，95%CI：1.37~2.23）。流感病毒在每年每个月都有检出，且 2013 年病毒活动有所增加。腺病毒和人偏肺病毒的感染具有明显的季节性模式。不同性别组之间的阳性率无显著差异，而不同年龄组之间的阳性率存在显著差异（P 值<0.001）。本研究证实，多种呼吸道病毒可能在人群中同时流行，在 ILI 的病因学中发挥重要作用。与呼吸道病毒相关的最常见症状是咽痛、流涕和头痛。临床医生在治疗 ILI 患者时需要考虑这些信息，政府官员在制定和实施有效的干预计划时也可以将这些信息作为参考。
