乙肝表面抗原（HBsAg）携带者母亲经胎盘传播乙肝病毒（HBV）感染缺乏证据。

Lack of evidence for transplacental transmission of HBV infection by HBsAg-carrier mothers.

作者信息

Ramia S, Al-Frayh A R, Bakir T M

机构信息

Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Ann Trop Paediatr. 1988 Sep;8(3):141-4. doi: 10.1080/02724936.1988.11748556.

DOI:10.1080/02724936.1988.11748556

PMID:2461147

Abstract

The possibility of transplacental transmission of HBV infection was investigated in 54 HBsAg-carrier Saudi mothers and their newborns. Controls were 60 Saudi mothers with previous exposure to HBV, and their newborns. Thirteen cord blood samples were HBsAg-positive by ELISA, including three from mothers with previous exposure to HBV, compared with one sample which was HBsAg- and HBeAg-positive and three samples which were only HBeAg-positive. Eight of the 13 cord blood samples which were HBsAg-positive by ELISA were haemolysed sera and were found to be HBsAg-negative by RIA and RPHA. None of the infants' sera, taken within 1-4 days of delivery, was positive for HBsAg or IgM anti-HBc. These results indicate that HBV markers in cord blood are either false-positive or due to contamination by maternal blood rather than an indication of in utero infection.

摘要

对54名携带乙肝表面抗原（HBsAg）的沙特母亲及其新生儿进行了乙肝病毒（HBV）感染经胎盘传播可能性的研究。对照组为60名曾接触过HBV的沙特母亲及其新生儿。通过酶联免疫吸附测定（ELISA），13份脐带血样本HBsAg呈阳性，其中包括3份来自曾接触过HBV母亲的样本；相比之下，有1份样本HBsAg和乙肝e抗原（HBeAg）均呈阳性，3份样本仅HBeAg呈阳性。13份经ELISA检测HBsAg呈阳性的脐带血样本中有8份为溶血血清，经放射免疫分析（RIA）和反向被动血凝试验（RPHA）检测发现其HBsAg呈阴性。在分娩后1 - 4天内采集的婴儿血清中，无一例HBsAg或抗-HBc IgM呈阳性。这些结果表明，脐带血中的HBV标志物要么是假阳性，要么是由于母体血液污染所致，而非子宫内感染的迹象。