Bissonette Gregory B, Gentry Ronny N, Padmala Srikanth, Pessoa Luiz, Roesch Matthew R
Department of Psychology, University of Maryland, College Park MD, USA.
Front Syst Neurosci. 2014 Mar 4;8:24. doi: 10.3389/fnsys.2014.00024. eCollection 2014.
Decision-making is motivated by the possibility of obtaining reward and/or avoiding punishment. Though many have investigated behavior associated with appetitive or aversive outcomes, few have examined behaviors that rely on both. Fewer still have addressed questions related to how anticipated appetitive and aversive outcomes interact to alter neural signals related to expected value, motivation, and salience. Here we review recent rodent, monkey, and human research that address these issues. Further development of this area will be fundamental to understanding the etiology behind human psychiatric diseases and cultivating more effective treatments.
决策是由获得奖励和/或避免惩罚的可能性所驱动的。尽管许多人研究了与奖赏性或厌恶性结果相关的行为，但很少有人研究依赖两者的行为。更少有人探讨与预期的奖赏性和厌恶性结果如何相互作用以改变与预期价值、动机和显著性相关的神经信号有关的问题。在这里，我们回顾了近期针对这些问题的啮齿动物、猴子和人类研究。该领域的进一步发展对于理解人类精神疾病背后的病因以及培养更有效的治疗方法至关重要。
