Hansen Dominique, Feys Peter, Wens Inez, Eijnde Bert O
Rehabilitation Research Centre (REVAL), Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan Building A, 3590 Diepenbeek, Belgium.
Mult Scler Int. 2014;2014:759030. doi: 10.1155/2014/759030. Epub 2014 Jan 29.
Background and Purpose. Walking capacity is reduced in subjects with multiple sclerosis (MS). To develop effective exercise interventions to enhance walking capacity, it is important to determine the impact of factors, modifiable by exercise intervention (maximal muscle strength versus muscle oxidative capacity), on walking capacity. The purpose of this pilot study is to discriminate between the impact of maximal muscle strength versus muscle oxidative capacity on walking capacity in subjects with MS. Methods. From 24 patients with MS, muscle oxidative capacity was determined by calculation of exercise-onset oxygen uptake kinetics (mean response time) during submaximal exercise bouts. Maximal muscle strength (isometric knee extension and flexion peak torque) was assessed on dynamometer. All subjects completed a 6-minute walking test. Relationships between walking capacity (as a percentage of normal value) and muscle strength (of knee flexors and extensors) versus muscle oxidative capacity were assessed in multivariate regression analyses. Results. The expanded disability status score (EDSS) showed a significant univariate correlation (r = -0.70, P < 0.004) with walking capacity. In multivariate regression analyses, EDSS and mean response time, but not muscle strength, were independently related to walking capacity (P < 0.05). Conclusions. Walking distance is, next to disability level and not taking neurologic symptoms/deficits into account, primarily related to muscle oxidative capacity in subjects with MS. Additional study is needed to further examine/verify these findings.
背景与目的。多发性硬化症（MS）患者的行走能力会下降。为了制定有效的运动干预措施来提高行走能力，确定可通过运动干预改变的因素（最大肌肉力量与肌肉氧化能力）对行走能力的影响非常重要。这项初步研究的目的是区分最大肌肉力量与肌肉氧化能力对MS患者行走能力的影响。方法。从24例MS患者中，通过计算次最大运动期间运动起始时的摄氧量动力学（平均反应时间）来确定肌肉氧化能力。在测力计上评估最大肌肉力量（等长膝关节伸展和屈曲峰值扭矩）。所有受试者均完成了6分钟步行测试。在多变量回归分析中评估了行走能力（作为正常值的百分比）与肌肉力量（膝关节屈肌和伸肌）与肌肉氧化能力之间的关系。结果。扩展残疾状态评分（EDSS）与行走能力呈显著单变量相关性（r = -0.70，P < 0.004）。在多变量回归分析中，EDSS和平均反应时间而非肌肉力量与行走能力独立相关（P < 0.05）。结论。除了残疾程度且不考虑神经症状/缺陷外，MS患者的行走距离主要与肌肉氧化能力有关。需要进一步的研究来进一步检查/验证这些发现。
