Abusailik Mohammad A, Muhanna Alsharif M, Almuhisen Adam A, Alhasanat Abdullah M, Alshamaseen Ayed M, Bani Mustafa Safa M, Nawaiseh Mohammed B
Department of Dermatology, Jordanian Royal Medical Services, Amman.
Department of Obstetrics and Gynecology, Jordanian Royal Medical Services, Amman.
Dermatol Reports. 2021 Sep 15;13(2):8799. doi: 10.4081/dr.2021.8799. eCollection 2021 Aug 1.
The aim of this cross-sectional study, that included 146 polycystic ovary syndrome (PCOS) patients, was to evaluate the prevalence, severity and pattern of cutaneous manifestation in Jordanian women with PCOS, as well as their correlation with hormonal abnormalities. A thorough complete cutaneous examination, hormonal assays (Luteinizing hormone [LH], follicle stimulating hormone [FSH], prolactin, total testosterone, free testosterone, dehydroepiandrosterone sulfate) and pelvic ultrasonography were done. The most common cutaneous features of PCOS were acne vulgaris (75.3%) followed by hirsutism (59.6%) then seborrhea (43.2%) and androgenetic alopecia (42.5%). Patients who had acne vulgaris presented at a younger age than patients who did not. Patients who had androgenetic alopecia and stria were older than patients with no such features. Moreover, all cutaneous manifestations of PCOS, except for acne, were associated with higher body mass index (BMI). Elevated LH:FSH ratio of more than 2:1 was the most common hormonal abnormality, followed by increased LH and total testosterone. Acne, hirsutism, androgenetic alopecia, seborrhea, acanthosis nigricans and skin tags are common cutaneous manifestations among Jordanian patients with PCOS. The existence of one or more of these features, especially in overweight and obese patients, should alert the physician towards the possibility of having PCOS.
这项横断面研究纳入了146名多囊卵巢综合征（PCOS）患者，旨在评估约旦PCOS女性皮肤表现的患病率、严重程度和模式，以及它们与激素异常的相关性。研究进行了全面的皮肤检查、激素检测（促黄体生成素[LH]、促卵泡生成素[FSH]、催乳素、总睾酮、游离睾酮、硫酸脱氢表雄酮）和盆腔超声检查。PCOS最常见的皮肤特征是寻常痤疮（75.3%），其次是多毛症（59.6%），然后是脂溢性皮炎（43.2%）和雄激素性脱发（42.5%）。患有寻常痤疮的患者比未患痤疮的患者发病年龄更小。患有雄激素性脱发和萎缩纹的患者比没有这些特征的患者年龄更大。此外，除痤疮外，PCOS的所有皮肤表现都与较高的体重指数（BMI）相关。LH:FSH比值大于2:1是最常见的激素异常，其次是LH和总睾酮升高。痤疮、多毛症、雄激素性脱发、脂溢性皮炎、黑棘皮病和皮肤软纤维瘤是约旦PCOS患者常见的皮肤表现。出现这些特征中的一种或多种，尤其是超重和肥胖患者，应提醒医生注意患PCOS的可能性。
