微生物、微生物组和结肠癌。
Microbes, microbiota, and colon cancer.
机构信息
Department of Medicine, Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
出版信息
Cell Host Microbe. 2014 Mar 12;15(3):317-28. doi: 10.1016/j.chom.2014.02.007.
Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.
结直肠癌（CRC）在全球范围内造成了相当大的疾病负担。人类结肠也是微生物数量最多的解剖部位。因此，可以预料微生物，特别是细菌，在结直肠发生癌变中起作用。微生物宏基因组学的日益普及，推动了我们对微生物和微生物群在 CRC 中作用的理解。在这篇综述中，我们将讨论微生物组对 CRC 的贡献的最新见解，并探讨评估微生物在癌症发病机制中的作用的概念框架。我们还重点介绍了关于潜在 CRC 促进物种的新发现和当前的知识空白。最后，我们探讨了微生物代谢与胆汁酸、外源性化合物和饮食在 CRC 的病因学和治疗中的关系。
Zotero 插件