Stolz Donna Beer, Sims-Lucas Sunder
Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Pediatr Nephrol. 2015 Jun;30(6):865-72. doi: 10.1007/s00467-014-2798-3. Epub 2014 Mar 15.
The renal vasculature, like all vessels, is lined by a thin layer of simple squamous epithelial cells called an endothelium. These endothelial-lined vessels can be subdivided into four major compartments: arteries, veins, capillaries and lymphatics. The renal vasculature is a highly integrated network that forms through the active processes of angiogenesis and vasculogenesis. Determination of the precise contribution of these two processes and of the molecular signaling that governs the differentiation, specification and maturation of these critical cell populations is the focus of an actively evolving field of research. Although much of the focus has concentrated on the origin of the glomerular capillaries, in this review we extend the investigation to the origins of the endothelial cells throughout the entire kidney and the signaling events that cause their distinct functional and molecular profiles. A thorough understanding of endothelial cell biology may play a critical role in a better understanding of renal vascular diseases.
肾血管系统与所有血管一样，由一层称为内皮的薄的单层鳞状上皮细胞所衬里。这些有内皮衬里的血管可细分为四个主要部分：动脉、静脉、毛细血管和淋巴管。肾血管系统是一个高度整合的网络，通过血管生成和血管发生的活跃过程形成。确定这两个过程的精确贡献以及控制这些关键细胞群的分化、特化和成熟的分子信号传导，是一个正在积极发展的研究领域的重点。尽管大部分研究集中在肾小球毛细血管的起源，但在本综述中，我们将研究扩展到整个肾脏内皮细胞的起源以及导致其独特功能和分子特征的信号事件。对内皮细胞生物学的透彻理解可能在更好地理解肾血管疾病中起关键作用。
