Medical University, Bialystok, Podlaskie, Poland,
Eur Child Adolesc Psychiatry. 2015 Jan;24(1):55-63. doi: 10.1007/s00787-014-0533-z. Epub 2014 Mar 17.
The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β = 0.33; p = 0.043) and HKD (β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019).
基质金属蛋白酶-9（MMP-9）在成人神经精神疾病中的血清水平已得到广泛研究。迄今为止，尚未有研究探讨 MMP-9与儿童两种表型模型（注意缺陷/多动障碍和多动障碍）认知领域之间的关系。本研究旨在评估和检验血清 MMP-9 水平与 ADHD/HKD 儿童症状严重程度相关的假设，并比较该疾病两种模型的结果。研究组包括 37 名年龄在 7-12 岁的白种人男孩，患有多动障碍，他们是联合注意缺陷多动障碍亚型的一部分。智力功能采用韦氏儿童智力量表修订版进行测量。MMP-9 血清浓度的分析基于定量夹心 ELISA。统计回归分析显示，血清 MMP-9 水平升高与 ADHD（β=0.33；p=0.043）和 HKD（β=0.34，p=0.037）模型中症状的严重程度相关。根据结果，患有多动障碍的男孩血清 MMP-9 水平升高可能与临床冲动性领域有关（β=0.38；p=0.019）。
