在表达反义RNA的原代人T细胞中抑制I型人T细胞白血病病毒的复制。
Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA.
作者信息
von Rüden T, Gilboa E
机构信息
Institute of Genetics, Johannes Gutenberg University of Mainz, Federal Republic of Germany.
出版信息
J Virol. 1989 Feb;63(2):677-82. doi: 10.1128/JVI.63.2.677-682.1989.
Abstract
The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express antisense RNA transcripts in primary human leukocytes. Human T-cell leukemia virus type I replication and virus-mediated immortalization were inhibited in cells harboring antisense constructs. This study suggests that retrovirus-mediated antisense RNA inhibition can be used to protect primary human T-lymphocytes from human T-cell leukemia virus type I-mediated cell transformation.
摘要
人类I型T细胞白血病病毒与人类成人T细胞白血病-淋巴瘤相关，该疾病由T淋巴细胞的恶性转化诱导产生。携带逆转录方向的人类I型T细胞白血病病毒衍生序列的逆转录病毒载体被用于在原代人白细胞中表达反义RNA转录物。在含有反义构建体的细胞中，人类I型T细胞白血病病毒的复制和病毒介导的永生化受到抑制。本研究表明，逆转录病毒介导的反义RNA抑制可用于保护原代人T淋巴细胞免受人类I型T细胞白血病病毒介导的细胞转化。
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