Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
J Nat Med. 2014 Jul;68(3):513-20. doi: 10.1007/s11418-014-0828-x. Epub 2014 Mar 16.
From the EtOAc-soluble fraction of a MeOH extract of leaves of Cinnamosma fragrans, seven new compounds, including 3,4-seco-24-homo-28-nor-cycloartane, drimane-type sesquiterpenes and their lactams, and two known compounds were isolated. Their structures were elucidated by extensive analyses of spectroscopic data. The cytotoxicity, anti-multidrug resistance activity, and anti-Leishmania activity of a cycloartane derivative and drimane-type sesquiterpene derivatives were assayed. The cycloartane derivative showed strong cytotoxicity, and some drimanes and drimane lactam showed moderate anti-multidrug resistance and anti-Leishmania activity.
从肉桂叶甲醇提取物的乙酸乙酯可溶部分中，分离得到了七种新化合物，包括 3,4-裂环-24-高-28-降环阿替烷、大根香叶烯型倍半萜及其内酰胺，以及两种已知化合物。通过对光谱数据的广泛分析，确定了它们的结构。对环阿替烷衍生物和大根香叶烯型倍半萜衍生物的细胞毒性、抗多药耐药性活性和抗利什曼原虫活性进行了测定。环阿替烷衍生物表现出很强的细胞毒性，一些大根香叶烯和大根香叶烯内酰胺表现出中度的抗多药耐药性和抗利什曼原虫活性。
