Centre de Recherche en Neurosciences de Lyon, CNRS UMR 5292, INSERM U 1028, Université Claude Bernard Lyon1, 69366 Lyon, France.
Learn Mem. 2014 Mar 14;21(4):185-9. doi: 10.1101/lm.033688.113.
To test the selectivity of the orexin A (OXA) system in olfactory sensitivity, the present study compared the effects of fasting and of central infusion of OXA on the memory processes underlying odor-malaise association during the conditioned odor aversion (COA) paradigm. Animals implanted with a cannula in the left ventricle received ICV infusion of OXA or artificial cerebrospinal fluid (ACSF) 1 h before COA acquisition. An additional group of intact rats were food-deprived for 24 h before acquisition. Results showed that the increased olfactory sensitivity induced by fasting and by OXA infusion was accompanied by enhanced COA performance. The present results suggest that fasting-induced central OXA release influenced COA learning by increasing not only olfactory sensitivity, but also the memory processes underlying the odor-malaise association.
为了测试食欲素 A（OXA）系统在嗅觉敏感性中的选择性，本研究比较了禁食和中枢注射 OXA 对条件性厌恶关联（COA）范式中气味不适关联记忆过程的影响。将导管植入左心室的动物在 COA 获得前 1 小时接受 OXA 或人工脑脊液（ACSF）的 ICV 输注。另一组完整的大鼠在获得前禁食 24 小时。结果表明，禁食和 OXA 输注引起的嗅觉敏感性增加伴随着 COA 表现的增强。本研究结果表明，禁食诱导的中枢 OXA 释放通过增加嗅觉敏感性和气味不适关联的记忆过程来影响 COA 学习。
