组织工程可灌注癌症模型
TISSUE ENGINEERING PERFUSABLE CANCER MODELS.
作者信息
Fong E L, Santoro M, Farach-Carson M C, Kasper F K, Mikos A G
机构信息
Department of Bioengineering, Rice University, Houston, TX 77030.
Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005.
出版信息
Curr Opin Chem Eng. 2014 Feb;3:112-117. doi: 10.1016/j.coche.2013.12.008.
The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.
目前，流体流动对癌症进展的影响尚未得到充分理解，这凸显了需要灌注肿瘤模型来填补这一知识空白。微流控肿瘤模型能够在高时空控制下对细胞水平的生物过程进行建模，已证明其作为研究细胞间相互作用、间质流对肿瘤迁移的影响以及血管屏障功能作用的平台具有适用性。为了考虑癌症生长和侵袭的多尺度性质，宏观模型也是必要的。在微观和宏观层面的肿瘤模型中考虑流体动力学，可能会大大提高我们更全面模拟肿瘤微环境的能力。
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