Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.
J Allergy Clin Immunol. 2014 Feb;133(2):318-23. doi: 10.1016/j.jaci.2013.12.1040.
IgE-mediated food allergy is a global health problem that affects millions of persons and affects every aspect of life for the patient. Developing effective treatment strategies to augment current practice standards of strict dietary avoidance of antigens and availability of self-injectable epinephrine has been a major focus of research teams, advocacy groups, funding agencies, and patients and their families. Significant progress has been made through the development of allergen-specific immunotherapy encompassing 3 major forms of treatment: oral, sublingual, and epicutaneous immunotherapy. These therapies are in various stages of clinical investigation, with some successes noted in clinical outcomes and modulation of immune mechanisms toward effective therapy. Here we review recent progress and areas of concern for the role of these forms of immunotherapy as an emerging treatment for food allergy.
免疫球蛋白 E 介导的食物过敏是一个全球性的健康问题，影响着数以百万计的人，并影响着患者生活的方方面面。开发有效的治疗策略来增强目前严格避免抗原的饮食和自我注射肾上腺素的现有实践标准一直是研究团队、宣传团体、资助机构以及患者及其家属的主要关注点。通过开发过敏原特异性免疫疗法，涵盖 3 种主要治疗形式：口服、舌下和皮内免疫疗法，已经取得了重大进展。这些疗法处于不同的临床研究阶段，在临床结果和免疫机制的调节方面取得了一些成功，朝着有效的治疗方向发展。在这里，我们回顾了这些免疫疗法作为一种新兴的食物过敏治疗方法的最新进展和关注领域。
