Salim Saad Y, Kaplan Gilaad G, Madsen Karen L
Department of Medicine; Faculty of Medicine and Dentistry; University of Alberta; Edmonton, AB Canada.
Department of Medicine and Community Health Sciences; University of Calgary; Calgary, AB Canada.
Gut Microbes. 2014 Mar-Apr;5(2):215-9. doi: 10.4161/gmic.27251. Epub 2013 Dec 20.
Global incidence rates for inflammatory bowel disease (IBD) have gradually risen over the past 20 years. Genome-wide association studies (GWAS) have identified over 160 genetic loci associated with IBD; however, inherited factors only account for a partial contribution to the disease risk. We have recently shown that urban airborne particulate matter (PM) ingested via contaminated food can alter gut microbiome and immune function under normal and inflammatory conditions. In this addendum, we will discuss how PM can modify the gut microbial form and function, provide evidence on changes seen in intestinal barrier, and suggest a working hypothesis of how pollutants affect the gastrointestinal tract. The significance of the work presented could lead to identifying airborne pollutants as potential risk factors and thus provide better patient care management.
在过去20年里，全球炎症性肠病（IBD）的发病率逐渐上升。全基因组关联研究（GWAS）已确定了160多个与IBD相关的基因位点；然而，遗传因素仅部分导致疾病风险。我们最近发现，通过受污染食物摄入的城市空气颗粒物（PM）可在正常和炎症条件下改变肠道微生物群和免疫功能。在本附录中，我们将讨论PM如何改变肠道微生物的形态和功能，提供肠道屏障变化的证据，并提出污染物影响胃肠道的工作假设。所展示工作的意义可能会将空气传播污染物确定为潜在风险因素，从而提供更好的患者护理管理。
