Hu Yongfei, Yang Xi, Lu Na, Zhu Baoli
CAS Key Laboratory of Pathogenic Microbiology & Immunology; Institute of Microbiology; Chinese Academy of Sciences; Beijing, China; Beijing Key Laboratory of Microbial Drug Resistance and Resistome; Beijing, China.
Gut Microbes. 2014 Mar-Apr;5(2):245-9. doi: 10.4161/gmic.27916. Epub 2014 Jan 31.
Increasing evidence has accumulated to support that the human gut is a reservoir for antibiotic resistance genes. We previously identified more than 1000 genes displaying high similarity with known antibiotic resistance genes in the human gut gene set generated from the Chinese, Danish, and Spanish populations. Here, first, we add our new understanding of antibiotic resistance genes in the US and the Japanese populations; next, we describe the structure of a vancomycin-resistant operon in a Danish sample; and finally, we provide discussions on the correlation of the abundance of resistance genes in human gut with the antibiotic consumption in human medicine and in animal husbandry. These results, combined with those we published previously, provide comprehensive insights into the antibiotic resistance genes in the human gut microbiota at a population level.
越来越多的证据表明，人类肠道是抗生素抗性基因的储存库。我们之前在中国、丹麦和西班牙人群的肠道基因集中鉴定出1000多个与已知抗生素抗性基因具有高度相似性的基因。在此，首先，我们补充了对美国和日本人群中抗生素抗性基因的新认识；其次，我们描述了丹麦一个样本中耐万古霉素操纵子的结构；最后，我们讨论了人类肠道中抗性基因丰度与人类医学和畜牧业抗生素使用量之间的相关性。这些结果与我们之前发表的结果相结合，在人群水平上为人类肠道微生物群中的抗生素抗性基因提供了全面的见解。
