Segal Barbara M, Rhodus Nelson, Moser Sivils Kathy L, Solid Craig A
From the Department of Medicine, and Department of Oral Surgery, University of Minnesota School of Dentistry; Minnesota Medical Research Foundation, Minneapolis, Minnesota; Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.B.M. Segal, MD, Department of Medicine, University of Minnesota; N. Rhodus, DDS, Department of Oral Surgery, University of Minnesota School of Dentistry; K.L. Moser Sivils, PhD, Oklahoma Medical Research Foundation; C.A. Solid, PhD, Minnesota Medical Research Foundation.
J Rheumatol. 2014 Oct;41(10):2027-33. doi: 10.3899/jrheum.140362. Epub 2014 Sep 15.
The Brief Cognitive Symptoms Inventory (BCSI) is a short, self-report scale designed to measure cognitive symptomatology in patients with rheumatic disease. To facilitate research and clinical practice, we tested the internal consistency and validity of the BCSI in patients with Sjögren syndrome (SS).
Patients who met the American-European Consensus Group criteria for SS and healthy controls completed a questionnaire assessing symptoms including cognitive complaints. We calculated Cronbach's alpha to assess internal consistency and Pearson correlation coefficients to test for association between BCSI, symptoms, and demographic variables. Total score distribution was analyzed to establish cutoff criteria for differentiation of case versus non-case. We compared neuropsychological outcomes of patients with SS above and below the threshold BCSI score to assess the association of cognitive symptoms with objective cognitive deficits.
Complete data were available on 144 patients with SS and 35 controls. Internal consistency of the BCSI was good. Scores were similar in all patient groups and patients reported more cognitive symptoms than controls (p < 0.0001). BCSI scores correlated moderately with pain, depression, anxiety, fatigue, and health quality. High scores for cognitive dysfunction were reported by 20% of the patients with SS and only 3% of controls. Patients with cognitive scores > 50 had more depression, fatigue, pain (effect size all > 1), and worse performance on multiple cognitive domains.
The BCSI should be a useful tool for the study of cognitive symptoms in SS. Both self-report and standardized tests should be considered in screening for cognitive disorders in SS.
简易认知症状量表（BCSI）是一种简短的自我报告量表，旨在测量风湿病患者的认知症状。为便于研究和临床实践，我们测试了BCSI在干燥综合征（SS）患者中的内部一致性和有效性。
符合美国-欧洲共识小组SS标准的患者和健康对照者完成了一份评估包括认知主诉在内症状的问卷。我们计算了Cronbach's α系数以评估内部一致性，并计算了Pearson相关系数以测试BCSI、症状和人口统计学变量之间的关联。分析总分分布以确定区分病例与非病例的临界标准。我们比较了BCSI分数高于和低于阈值的SS患者的神经心理学结果，以评估认知症状与客观认知缺陷之间的关联。
144例SS患者和35例对照者有完整数据。BCSI的内部一致性良好。所有患者组的分数相似，患者报告的认知症状多于对照者（p < 0.0001）。BCSI分数与疼痛、抑郁、焦虑、疲劳和健康质量呈中度相关。20%的SS患者报告有认知功能障碍高分，而对照者中只有3%。认知分数>50的患者有更多抑郁、疲劳、疼痛（效应量均>1），并且在多个认知领域表现更差。
BCSI应该是研究SS认知症状的有用工具。在筛查SS认知障碍时应同时考虑自我报告和标准化测试。
