Luteijn Johannes Michiel, Dolk Helen, Addor Marie-Claude, Arriola Larraitz, Barisic Ingeborg, Bianchi Fabrizio, Calzolari Elisa, Draper Elizabeth, Garne Ester, Gatt Miriam, Haeusler Martin, Khoshnood Babak, McDonnell Bob, Nelen Vera, O'Mahony Mary, Mullaney Carmel, Queisser-Luft Annette, Rankin Judith, Tucker David, Verellen-Dumoulin Christine, de Walle Hermien, Yevtushok Lyubov
Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom.
Birth Defects Res A Clin Mol Teratol. 2014 Apr;100(4):260-9. doi: 10.1002/bdra.23231. Epub 2014 Mar 17.
This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors.
Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population-based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza.
We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed.
We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies.
本研究描述了欧洲先天性异常的季节性，以提供一个基线，据此评估特定随时间变化的暴露因素（如甲型H1N1流感大流行）的影响，并提供季节性及其与病因学因素可能关系的全面且最新的情况。
从欧洲14个国家的20个基于人群的先天性异常登记处提取了2000年至2008年受孕出生的数据。我们进行了包含正弦和余弦项的泊松回归分析，以调查65764例非染色体性和12682例染色体性先天性异常（涵盖330万例出生）的季节性。分析按估计受孕月份进行。对86个先天性异常亚组进行了分析，包括一个先前与流感相关的先天性异常合并亚组。
我们在先前与流感相关的异常患病率中检测到具有统计学意义的季节性，但受孕高峰在6月（高出2.4%）。我们还在先天性白内障（4月受孕，27%）、髋关节脱位和/或发育不良（4月，12%）、先天性肾积水（7月，12%）、泌尿系统缺陷（7月，5%）以及内脏反位（12月，36%）中检测到季节性，但在合并的非染色体异常、合并的染色体异常或其他分析的异常中未检测到。
我们证实了先前描述的先天性白内障和髋关节脱位和/或发育不良的季节性，并发现了先天性肾积水和内脏反位的季节性，此前尚未对其进行过研究。我们没有找到先前被发现具有季节性的几种异常存在季节性的证据。流感似乎不是先天性异常季节性的重要因素。
