Mehryan Pedram, Zartab Hamed, Rajabi Ali, Pazhoohi Neda, Firooz Alireza
Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
J Cosmet Dermatol. 2014 Mar;13(1):72-8. doi: 10.1111/jocd.12072.
Infraorbital skin hyperpigmentation, commonly called dark circles, and crow's feet wrinkles are common cosmetic concerns. Various methods of treatment have been evaluated with variable outcomes.
This study was performed to assess the efficacy of platelet-rich plasma (PRP) injection for treating periorbital dark circles and crow's feet.
Ten participants with a mean age of 41.2 years were treated in a single session with intradermal injections of 1.5 mL PRP into tear trough area and crow's feet wrinkles on each side. The effects on melanin content, color homogeneity of the treated area, epidermal stratum corneum hydration, and wrinkle volume and visibility index were compared 3 months after treatment with baseline. Physician's global assessment and participants' satisfaction and any potential side effects were also assessed.
The improvement in infraorbital color homogeneity was statistically significant (P = 0.010), but no statistically significant changes were observed in melanin content, stratum corneum hydration, wrinkle volume, and visibility index. Participant's satisfaction score and physician's global assessment score were 2.2 and 1.7, respectively, on a 0-3 scale.
Platelet-rich plasma may have the potential to improve infraorbital dark circle in terms of color homogeneity of the region, though this remains to be proven using larger, controlled studies using multiple injections.
眶下皮肤色素沉着，通常称为黑眼圈，以及鱼尾纹是常见的美容问题。已经评估了各种治疗方法，结果各不相同。
本研究旨在评估富血小板血浆（PRP）注射治疗眶周黑眼圈和鱼尾纹的疗效。
10名平均年龄为41.2岁的参与者接受单次治疗，在泪沟区域和双侧鱼尾纹处皮内注射1.5 mL PRP。治疗3个月后，将治疗区域的黑色素含量、颜色均匀性、表皮角质层水合作用、皱纹体积和可见度指数与基线进行比较。还评估了医生的整体评估、参与者的满意度以及任何潜在的副作用。
眶下颜色均匀性的改善具有统计学意义（P = 0.010），但黑色素含量、角质层水合作用、皱纹体积和可见度指数未观察到统计学上的显著变化。在0-3的评分量表上，参与者的满意度得分和医生的整体评估得分分别为2.2和1.7。
富血小板血浆可能有改善眶下黑眼圈区域颜色均匀性的潜力，不过这仍有待通过使用多次注射的更大规模对照研究来证实。
