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AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.脂联素受体 1/2 双重激动剂通过内质网-线粒体轴恢复非酒精性脂肪性肝炎及相关肝纤维化。
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本文引用的文献

1
Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis.体重增加导致脂联素信号转导减少，通过损害线粒体生物发生导致非酒精性脂肪性肝炎。
Hepatology. 2014 Jul;60(1):133-45. doi: 10.1002/hep.26946. Epub 2014 May 27.
2
Adiponectin signaling in the liver.肝内脂联素信号通路。
Rev Endocr Metab Disord. 2014 Jun;15(2):137-47. doi: 10.1007/s11154-013-9280-6.
3
Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).多种打击，包括氧化应激，作为非酒精性脂肪性肝炎（NASH）的发病机制和治疗靶点。
Int J Mol Sci. 2013 Oct 15;14(10):20704-28. doi: 10.3390/ijms141020704.
4
Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease.维生素D缺乏与全身脂肪量增加及非酒精性脂肪性肝病的更严重程度相关。
Liver Int. 2014 Jul;34(6):e118-27. doi: 10.1111/liv.12312. Epub 2013 Oct 1.
5
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity.在肥胖期间，Pid1在人类和小鼠骨骼肌中均会引发胰岛素抵抗。
Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8.
6
Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994.非酒精性脂肪性肝病在美国的流行情况：第三次国家健康和营养检查调查，1988-1994 年。
Am J Epidemiol. 2013 Jul 1;178(1):38-45. doi: 10.1093/aje/kws448. Epub 2013 May 23.
7
Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?决定代谢综合征风险的因素：脂联素是否起核心作用？
Eur J Clin Nutr. 2013 May;67(5):485-91. doi: 10.1038/ejcn.2013.1. Epub 2013 Jan 30.
8
Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation.线粒体在非酒精性脂肪性肝病中的作用——从起源到进展。
Clin Biochem. 2012 Jun;45(9):610-8. doi: 10.1016/j.clinbiochem.2012.03.024. Epub 2012 Mar 28.
9
The multi-level action of fatty acids on adiponectin production by fat cells.脂肪酸对脂肪细胞脂联素生成的多层次作用。
PLoS One. 2011;6(11):e28146. doi: 10.1371/journal.pone.0028146. Epub 2011 Nov 29.
10
Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice.肌肉生长抑制素缺失对高脂肪喂养五个月的小鼠体重增加、高血糖和肝脂肪变性的影响。
PLoS One. 2011 Feb 24;6(2):e17090. doi: 10.1371/journal.pone.0017090.

Is the adiponectin-AMPK-mitochondrial axis involved in progression of nonalcoholic fatty liver disease?

作者信息

Dasarathy Srinivasan

机构信息

Department of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, OH.

出版信息

Hepatology. 2014 Jul;60(1):22-5. doi: 10.1002/hep.27134. Epub 2014 May 6.

DOI:10.1002/hep.27134
PMID:24644076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4482450/
Abstract
摘要