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在钛合金植入物上进行磷酸钙涂层的替代技术。

Alternative technique for calcium phosphate coating on titanium alloy implants.

作者信息

Le Van Quang, Pourroy Geneviève, Cochis Andrea, Rimondini Lia, Abdel-Fattah Wafa I, Mohammed Hadeer I, Carradò Adele

机构信息

Institut de Physique et Chimie des Matériaux de Strasbourg CNRS-UMR 7504; Strasbourg, France.

Department of Health Sciences; Università del Piemonte Orientale "Amedeo Avogadro"; Novara, Italy.

出版信息

Biomatter. 2014;4:e28534. doi: 10.4161/biom.28534. Epub 2014 Mar 19.

DOI:10.4161/biom.28534
PMID:24646569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4010538/
Abstract

As an alternative technique for calcium phosphate coating on titanium alloys, we propose to functionalize the metal surface with anionic bath containing chlorides of palladium or silver as activators. This new deposition route has several advantages such as controlled conditions, applicability to complex shapes, no adverse effect of heating, and cost effectiveness. A mixture of hydroxyapatite and calcium phosphate hydrate is deposited on the surface of Ti-6Al-4V. Calcium phosphate coating is built faster compared with the one by Simulated Body Fluid. Cell morphology and density are comparable to the control one; and the results prove no toxic compound is released into the medium during the previous seven days of immersion. Moreover, the cell viability is comparable with cells cultivated with the virgin medium. These experimental treatments allowed producing cytocompatible materials potentially applicable to manufacture implantable devices for orthopedic and oral surgeries.

摘要

作为在钛合金上进行磷酸钙涂层的另一种技术，我们建议用含有钯或银的氯化物作为活化剂的阴离子浴对金属表面进行功能化处理。这种新的沉积途径具有若干优点，如条件可控、适用于复杂形状、无加热的不利影响以及成本效益高。羟基磷灰石和水合磷酸钙的混合物沉积在Ti-6Al-4V表面。与通过模拟体液形成的涂层相比，磷酸钙涂层形成得更快。细胞形态和密度与对照相当；结果证明在浸泡的前七天内没有有毒化合物释放到培养基中。此外，细胞活力与用原始培养基培养的细胞相当。这些实验处理使得能够生产出具有细胞相容性的材料，有可能应用于制造骨科和口腔手术的可植入装置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/34aa82bccbe5/biom-4-e28534-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/337917e5f53d/biom-4-e28534-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/7659e0c17b3b/biom-4-e28534-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/886f6754535e/biom-4-e28534-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/205e14dde1d6/biom-4-e28534-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/9e094049956d/biom-4-e28534-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/400e5584206a/biom-4-e28534-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/d4140963b18e/biom-4-e28534-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/34aa82bccbe5/biom-4-e28534-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/337917e5f53d/biom-4-e28534-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/7659e0c17b3b/biom-4-e28534-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/886f6754535e/biom-4-e28534-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/205e14dde1d6/biom-4-e28534-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/9e094049956d/biom-4-e28534-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/400e5584206a/biom-4-e28534-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/d4140963b18e/biom-4-e28534-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a6d/4010538/34aa82bccbe5/biom-4-e28534-g7.jpg

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A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices.银作为医疗器械抗菌剂的药理毒理学概况。
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Nanosilver as a new generation of nanoproduct in biomedical applications.纳米银作为新一代纳米产品在生物医学中的应用。
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Structural, microstructural, and residual stress investigations of plasma-sprayed hydroxyapatite on Ti-6Al-4 V.
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