DU Yingying, Hu Lixia, Pan Yueyin
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Biomed Rep. 2013 Mar;1(2):269-274. doi: 10.3892/br.2013.56. Epub 2013 Jan 17.
FAS/FASL gene promoter polymorphisms are associated with cervical cancer risk, however, results from previous studies have been conflicting. To obtain a more precise estimation of the association between these polymorphisms and cancer risk, a meta-analysis was performed. All eligible studies up to November 1st, 2012, concerning FAS-670 A/G, FAS-1377 G/A and FASL-844 T/C polymorphisms and cervical cancer risk, were collected from the following electronic databases: PubMed, Excerpta Medica Database and Chinese Biomedical Literature Database. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the association via the additive, codominant, dominant and recessive models. In total, 10 publications with 11 case-control studies (10 on FAS-670 A/G, 5 on FAS-1377 G/A and 6 on FASL-844 T/C polymorphisms) were included in this meta-analysis. No association between FAS-670 A/G, FAS-1377 G/A and FASL-844 T/C polymorphisms and cervical cancer susceptibility for all the genetic models was identified. Following stratification of the studies by ethnicity or source of controls, similar results were obtained. In conclusion, our findings showed that the FAS-670 A/G, FAS-1377 G/A and FASL-844 T/C polymorphisms are not associated with cervical cancer risk. Future studies with larger sample sizes are required to further evaluate these associations.
FAS/FASL基因启动子多态性与宫颈癌风险相关，然而，以往研究的结果一直存在矛盾。为了更精确地估计这些多态性与癌症风险之间的关联，我们进行了一项荟萃分析。从以下电子数据库中收集了截至2012年11月1日的所有符合条件的研究，这些研究涉及FAS - 670 A/G、FAS - 1377 G/A和FASL - 844 T/C多态性与宫颈癌风险：PubMed、医学文摘数据库和中国生物医学文献数据库。通过相加模型、共显性模型、显性模型和隐性模型，使用比值比（OR）和95%置信区间（95%CI）来评估关联强度。本荟萃分析共纳入了10篇文献，包含11项病例对照研究（10项关于FAS - 670 A/G，5项关于FAS - 1377 G/A，6项关于FASL - 844 T/C多态性）。在所有遗传模型中，均未发现FAS - 670 A/G、FAS - 1377 G/A和FASL - 844 T/C多态性与宫颈癌易感性之间存在关联。按种族或对照来源对研究进行分层后，得到了类似的结果。总之，我们的研究结果表明，FAS - 670 A/G、FAS - 1377 G/A和FASL - 844 T/C多态性与宫颈癌风险无关。需要进一步开展更大样本量的研究来评估这些关联。
