肿瘤微环境中的间充质干细胞
Mesenchymal stem cells in the tumor microenvironment.
作者信息
Guan Jian, Chen Jie
机构信息
Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, P.R. China.
出版信息
Biomed Rep. 2013 Jul;1(4):517-521. doi: 10.3892/br.2013.103. Epub 2013 May 10.
Abstract
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent cells, which are able to differentiate to bone, adipose and cartilage tissue. MSCs have the characteristic of migration to injured areas or tumor microenvironment following induction by chemokines or inflammatory factors. An increasing number of studies have reported that MSCs recruited to the tumor microenvironment play various roles in tumor cell development and tumor progression. In this study, we reviewed the studies related to the tumor-promoting roles of MSCs from several aspects, such as increasing stemness of tumor cells, mediating migration, promoting angiogenesis, suppressing immune response and inducing drug resistance.
摘要
间充质干细胞（MSCs）是一种非造血多能细胞，能够分化为骨、脂肪和软骨组织。MSCs具有在趋化因子或炎症因子诱导下迁移至损伤区域或肿瘤微环境的特性。越来越多的研究报道，募集至肿瘤微环境的MSCs在肿瘤细胞发展和肿瘤进展中发挥多种作用。在本研究中，我们从几个方面综述了与MSCs促肿瘤作用相关的研究，如增加肿瘤细胞干性、介导迁移、促进血管生成、抑制免疫反应和诱导耐药性。
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