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肿瘤微环境中的间充质干细胞

Mesenchymal stem cells in the tumor microenvironment.

作者信息

Guan Jian, Chen Jie

机构信息

Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, P.R. China.

出版信息

Biomed Rep. 2013 Jul;1(4):517-521. doi: 10.3892/br.2013.103. Epub 2013 May 10.

DOI:10.3892/br.2013.103
PMID:24648978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3916973/
Abstract

Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent cells, which are able to differentiate to bone, adipose and cartilage tissue. MSCs have the characteristic of migration to injured areas or tumor microenvironment following induction by chemokines or inflammatory factors. An increasing number of studies have reported that MSCs recruited to the tumor microenvironment play various roles in tumor cell development and tumor progression. In this study, we reviewed the studies related to the tumor-promoting roles of MSCs from several aspects, such as increasing stemness of tumor cells, mediating migration, promoting angiogenesis, suppressing immune response and inducing drug resistance.

摘要

间充质干细胞（MSCs）是一种非造血多能细胞，能够分化为骨、脂肪和软骨组织。MSCs具有在趋化因子或炎症因子诱导下迁移至损伤区域或肿瘤微环境的特性。越来越多的研究报道，募集至肿瘤微环境的MSCs在肿瘤细胞发展和肿瘤进展中发挥多种作用。在本研究中，我们从几个方面综述了与MSCs促肿瘤作用相关的研究，如增加肿瘤细胞干性、介导迁移、促进血管生成、抑制免疫反应和诱导耐药性。

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本文引用的文献

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Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study.自体骨髓来源间充质基质细胞治疗肾移植后移植物排斥反应：Ⅰ期研究结果。
Stem Cells Transl Med. 2013 Feb;2(2):107-11. doi: 10.5966/sctm.2012-0114. Epub 2013 Jan 24.
2
Hypoxia induces osteogenic/angiogenic responses of bone marrow-derived mesenchymal stromal cells seeded on bone-derived scaffolds via ERK1/2 and p38 pathways.缺氧通过 ERK1/2 和 p38 通路诱导骨髓间充质基质细胞在骨源性支架上的成骨/血管生成反应。
Biotechnol Bioeng. 2013 Jun;110(6):1794-804. doi: 10.1002/bit.24827. Epub 2013 Jan 17.
3
Mesenchymal stromal cells to promote solid organ transplantation tolerance.间充质基质细胞促进实体器官移植耐受。
Curr Opin Organ Transplant. 2013 Feb;18(1):51-8. doi: 10.1097/MOT.0b013e32835c5016.
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Cellular and molecular interactions of mesenchymal stem cells in innate immunity.间充质干细胞在天然免疫中的细胞和分子相互作用。
Immunol Cell Biol. 2013 Jan;91(1):27-31. doi: 10.1038/icb.2012.62. Epub 2012 Nov 13.
5
Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells.间质干细胞调节胰腺癌细胞的上皮间质转化和肿瘤进展。
Cancer Sci. 2013 Feb;104(2):157-64. doi: 10.1111/cas.12059. Epub 2013 Jan 11.
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Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers.人骨髓间充质干细胞和上皮性肝癌细胞系的混合物：同时刺激癌相关成纤维细胞和上皮-间充质转化标志物。
Surgery. 2012 Sep;152(3):449-54. doi: 10.1016/j.surg.2012.06.011.
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Mol Med Rep. 2012 Nov;6(5):955-60. doi: 10.3892/mmr.2012.1019. Epub 2012 Aug 7.