Koba Chiharu, Koga Chihiro, Cho Tamaki, Kusukawa Jingo
Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Department of Oral and Maxillofacial Surgery, Center for Oral Diseases, Fukuoka Dental College, Kurume, Fukuoka 8140175, Japan.
Biomed Rep. 2013 Jul;1(4):529-533. doi: 10.3892/br.2013.112. Epub 2013 May 22.
With the growing number of elderly individuals, Candida is occasionally recognised as a fungal cause of aspiration pneumonia. In addition, there are numerous investigational reports on oral candidiasis. However, there are currently no reports on Candida contamination of denture base materials. This study was conducted to investigate Candida species in the oral cavity, denture parts and oral lesions of older/elderly subjects with oral candidiasis. The Candida strains were isolated and the species identified. Candida was also cultured in a medium with sample of denture resin and observed under an electron microscope. The results demonstrated the presence of several Candida species in the lesions of the oral mucosa and the surface and inner portions of the dentures. The following species of Candida were detected: , , and . Using electron microscopy, the invasion of Candida was observed in the incomplete polymerized resin base material and/or through microcracks (fissures) that have a tendency to form in used dentures. It was concluded that Candida may be present on the surface as well as the deeper portions of dentures. In addition, it appeared necessary to consider denture and oral cavity cleaning and the risks of remaking old dentures.
随着老年人口数量的增加，念珠菌偶尔被认为是吸入性肺炎的真菌病因。此外，有许多关于口腔念珠菌病的研究报告。然而，目前尚无关于义齿基托材料念珠菌污染的报告。本研究旨在调查患有口腔念珠菌病的老年受试者口腔、义齿部件及口腔病变中的念珠菌种类。分离念珠菌菌株并鉴定其种类。念珠菌还在含有义齿树脂样本的培养基中培养，并在电子显微镜下观察。结果表明，在口腔黏膜病变以及义齿表面和内部存在多种念珠菌。检测到以下念珠菌种类： 、 、 和 。使用电子显微镜观察到，念珠菌侵入未完全聚合的树脂基托材料和/或使用过的义齿中容易形成的微裂纹（裂缝）。得出的结论是，念珠菌可能存在于义齿的表面以及更深层部位。此外，似乎有必要考虑义齿和口腔清洁以及重新制作旧义齿的风险。
