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Exp Ther Med. 2012 Apr;3(4):689-692. doi: 10.3892/etm.2012.469. Epub 2012 Feb 3.
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Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.MiRSNPs 对接受自体干细胞移植的多发性骨髓瘤患者生存和进展的影响。
Clin Cancer Res. 2012 Jul 1;18(13):3697-704. doi: 10.1158/1078-0432.CCR-12-0191. Epub 2012 Apr 26.
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A polymorphism at the miR-502 binding site in the 3'-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome.miR-502 结合位点的多态性位于组蛋白甲基转移酶 SET8 的 3'-非翻译区，与肝细胞癌的预后相关。
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Lung Cancer. 2011 Jun;72(3):271-9. doi: 10.1016/j.lungcan.2011.02.014. Epub 2011 Mar 26.
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该基因的一个与微小RNA相关的单核苷酸多态性与小细胞肺癌患者的生存率相关。

A microRNA-related single nucleotide polymorphism of the gene is associated with survival of small cell lung cancer patients.

作者信息

Guo Zhanjun, Wang Hongjing, Li Yantao, Li Bin, Li Cuiqiao, Ding Cuimin

机构信息

Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

出版信息

Biomed Rep. 2013 Jul;1(4):545-548. doi: 10.3892/br.2013.92. Epub 2013 Mar 29.

DOI:10.3892/br.2013.92
PMID:24648983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3917003/
Abstract

MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes affect cancer risk, treatment efficacy and patient prognosis. A miR-SNP of rs11077 located in the 3'UTR of miRNA processing machinery gene was examined in small cell lung cancer (SCLC) patients to evaluate its association with cancer survival. A total of 42 patients were enrolled in the present study and genotyped for rs11077 and survival was assessed using the Kaplan-Meier method, as well as univariate and multivariate analyses. The AA genotype of rs11077 was identified for its significant association with better survival time (P=0.023). In addition, rs11077 was found to associate independently with overall survival in SCLC patients by multivariate analysis (relative risk 2.469; 95% CI, 1.088-5.603; P=0.031). The findings of this study suggest that although miR-SNP studies for miRNA processing machinery genes are still at an early age, miR-SNPs have an impact on cancer survival. In conclusion, a miR-SNP in the 3'UTR region of the gene was identified as an independent prognostic marker for survival of advanced SCLC patients.

摘要

微小RNA（miRNA）加工机制基因中的微小RNA（miRNA）相关单核苷酸多态性（miR-SNP）影响癌症风险、治疗效果和患者预后。在小细胞肺癌（SCLC）患者中检测了位于miRNA加工机制基因3'非翻译区（3'UTR）的rs11077的miR-SNP，以评估其与癌症生存率的相关性。本研究共纳入42例患者，对rs11077进行基因分型，并采用Kaplan-Meier法以及单因素和多因素分析评估生存率。rs11077的AA基因型被确定与更好的生存时间显著相关（P=0.023）。此外，多因素分析发现rs11077与SCLC患者的总生存率独立相关（相对风险2.469；95%可信区间，1.088-5.603；P=0.031）。本研究结果表明，尽管针对miRNA加工机制基因的miR-SNP研究仍处于早期阶段，但miR-SNP对癌症生存率有影响。总之，基因3'UTR区域的一个miR-SNP被确定为晚期SCLC患者生存的独立预后标志物。