Nordin C
Department of Psychiatry, Karolinska Institute, Huddinge Hospital, Sweden.
Acta Psychiatr Scand. 1988 Dec;78(6):720-9. doi: 10.1111/j.1600-0447.1988.tb06411.x.
In 28 patients with primary depression, relationships were sought between rating scores on the Montgomery-Asberg Depression Rating Scale and the concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) in cerebrospinal fluid (CSF). Among the single items in the rating scale, reported sadness correlated negatively with HMPG. No other significant relationships were found in the total group of patients. However, in subgroups with low or high concentrations of monoamine metabolites, several significant relationships were found, such as a negative correlation between inner tension and concentration difficulties, respectively, and 5-HIAA in the low-HMPG subgroup. Curvilinear relationships were found between pessimistic thoughts and 5-HIAA in the high-5-HIAA subgroup and between apparent sadness and 5-HIAA in the low-HMPG subgroup. Suicidal thoughts tended to correlate in a curvilinear way with the ratio of HMPG/5-HIAA in the low-HVA and the high-HMPG subgroups, but the curves were mirrored. The results indicate that relationships between clinical symptoms and monoamine metabolite homeostasis in CSF are qualitatively and quantitatively different in defined high-and low-monoamine subgroups of depressed patients.
在28例原发性抑郁症患者中，研究了蒙哥马利-阿斯伯格抑郁评定量表的评分与脑脊液（CSF）中5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）和4-羟基-3-甲氧基苯乙二醇（HMPG）这三种单胺代谢产物浓度之间的关系。在评定量表的单项中，报告的悲伤情绪与HMPG呈负相关。在全部患者组中未发现其他显著关系。然而，在单胺代谢产物浓度低或高的亚组中，发现了一些显著关系，例如在低HMPG亚组中，内心紧张和注意力不集中分别与5-HIAA呈负相关。在高5-HIAA亚组中，悲观想法与5-HIAA之间以及在低HMPG亚组中，明显悲伤与5-HIAA之间均发现了曲线关系。在低HVA和高HMPG亚组中，自杀念头与HMPG/5-HIAA的比值倾向于呈曲线相关，但曲线呈镜像关系。结果表明，在抑郁症患者明确的高单胺和低单胺亚组中，临床症状与脑脊液中单胺代谢产物稳态之间的关系在质量和数量上存在差异。
