Peabody C A, Faull K F, King R J, Whiteford H A, Barchas J D, Berger P A
Psychiatry Res. 1987 May;21(1):1-7. doi: 10.1016/0165-1781(87)90056-4.
Cerebrospinal fluid (CSF) amine metabolites were measured in 37 male subjects with major depressive disorder. Scores on the Hamilton Rating Scale for Depression (HRSD) correlated significantly with 5-hydroxyindoleacetic acid (5HIAA) and with homovanillic acid (HVA). In addition, the single suicide item of the HRSD correlated significantly with 5HIAA. Further, 5HIAA and HVA correlated significantly with each other. There was a significant positive correlation between HVA and two HRSD items, the depersonalization/derealization item and the paranoid item. Since lumbar CSF metabolite concentrations may reflect central nervous system activity of parent amines, these data suggest a relationship between depression and decreased dopaminergic and serotonergic activity.
对37名患有重度抑郁症的男性受试者的脑脊液（CSF）胺类代谢物进行了测量。汉密尔顿抑郁量表（HRSD）评分与5-羟吲哚乙酸（5HIAA）和高香草酸（HVA）显著相关。此外，HRSD中的单一自杀项目与5HIAA显著相关。此外，5HIAA和HVA之间也显著相关。HVA与HRSD的两个项目，即人格解体/现实解体项目和偏执项目之间存在显著正相关。由于腰椎脑脊液代谢物浓度可能反映母体胺类的中枢神经系统活动，这些数据表明抑郁症与多巴胺能和5-羟色胺能活性降低之间存在关联。
