Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States.
Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States.
Curr Opin Neurobiol. 2014 Jun;26:15-21. doi: 10.1016/j.conb.2013.10.002. Epub 2013 Nov 19.
Convention holds that ionotropic receptors mediate fast neurotransmission and that 'slow' G-protein coupled metabotropic receptors have a secondary, modulatory role in the control of neuronal networks. Here, we discuss recent evidence showing that activation of metabotropic GABAB receptors in cortical layer 1 can powerfully inhibit principal cell activity and that their activation can rapidly halt ongoing network activity. Inputs from both within and without the cortex converge upon layer 1 where they target various populations of interneurons, including neurogliaform cells. We argue that neurogliaform cells are the main effector of a powerful inhibitory circuit that, acting through GABAB receptors, can be differentially recruited by long-range connections to serve in roles as diverse as conscious perception and memory consolidation.
传统观点认为离子型受体介导快速神经递质传递，而“慢”G 蛋白偶联代谢型受体在神经元网络的控制中具有次要的调节作用。在这里，我们讨论了最近的证据，表明皮质层 1 中的代谢型 GABAB 受体的激活可以强有力地抑制主细胞活动，并且它们的激活可以迅速停止正在进行的网络活动。来自皮质内外的输入汇聚在层 1 上，它们作用于各种中间神经元群体，包括神经胶质细胞。我们认为神经胶质细胞是一个强大的抑制性回路的主要效应器，该回路通过 GABAB 受体作用，可以通过长程连接的不同招募，在意识知觉和记忆巩固等各种角色中发挥作用。
