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本文引用的文献

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Mycobacterial prosthetic valve endocarditis.分枝杆菌性人工心脏瓣膜心内膜炎。
Curr Infect Dis Rep. 2010 Jul;12(4):257-65. doi: 10.1007/s11908-010-0108-1.
2
Nontuberculous mycobacterial blood stream and cardiac infections in patients without HIV infection.非结核分枝杆菌血流和心脏感染，发生于无 HIV 感染的患者中。
Diagn Microbiol Infect Dis. 2010 Jul;67(3):286-90. doi: 10.1016/j.diagmicrobio.2010.02.006. Epub 2010 May 11.
3
Mycobacterium chelonae valve endocarditis resulting from contaminated biological prostheses.分枝杆菌龟型亚种心内膜炎由污染的生物假体引起。
J Infect. 2010 Jun;60(6):467-73. doi: 10.1016/j.jinf.2010.03.008. Epub 2010 Mar 20.
4
Native double-valve endocarditis by Mycobacterium fortuitum following percutaneous coronary intervention.经皮冠状动脉介入治疗后由偶然分枝杆菌引起的原发性双瓣膜心内膜炎。
J Heart Valve Dis. 2006 Nov;15(6):836-8.
5
Conservative treatment of prosthetic valve endocarditis due to Mycobacterium fortuitum.偶然分枝杆菌所致人工瓣膜心内膜炎的保守治疗
Eur J Clin Microbiol Infect Dis. 2002 Jul;21(7):539-41. doi: 10.1007/s10096-002-0763-8. Epub 2002 Jul 10.
6
Mycobacterium fortuitum endocarditis and meningitis after balloon mitral valvotomy.球囊二尖瓣成形术后的偶然分枝杆菌性心内膜炎和脑膜炎。
J Assoc Physicians India. 1999 Oct;47(10):1022-3.
7
Skin, soft tissue, and bone infections due to Mycobacterium chelonae chelonae: importance of prior corticosteroid therapy, frequency of disseminated infections, and resistance to oral antimicrobials other than clarithromycin.龟分枝杆菌引起的皮肤、软组织和骨感染：先前使用皮质类固醇治疗的重要性、播散性感染的频率以及对除克拉霉素以外的口服抗菌药物的耐药性
J Infect Dis. 1992 Aug;166(2):405-12. doi: 10.1093/infdis/166.2.405.
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Mycobacterium gordonae infection of a prosthetic aortic valve.
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一名患有风湿性心脏病的免疫功能正常患者发生由快速生长的非结核分枝杆菌龟分枝杆菌引起的自发性心内膜炎。

Spontaneous endocarditis caused by rapidly growing non-tuberculous Mycobacterium chelonae in an immunocompetent patient with rheumatic heart disease.

作者信息

Jagadeesan Naveena, Patra Soumya, Singh Ajit Pal, Nagesh Chamrajnagar Mahadevappa, Reddy Babu, Badnur Srinivas C, Nanjappa Manjunath Cholenahally

机构信息

Department of Microbiology, Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bangalore 560069, Karnataka, India.

Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bangalore 560069, Karnataka, India.

出版信息

J Cardiovasc Dis Res. 2013 Dec;4(4):254-6. doi: 10.1016/j.jcdr.2013.06.003. Epub 2013 Aug 21.

DOI:10.1016/j.jcdr.2013.06.003
PMID:24653593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3953690/
Abstract

We are reporting the first case of spontaneous endocarditis caused by rapid grower non-tuberculous Mycobacterium chelonae in a case of rheumatic heart disease. The diagnosis was confirmed as there was repeated isolation of rapidly growing atypical Mycobacterium from blood culture which was identified as M. chelonae by Reverse line probe assay. The patient presented with pyrexia of unknown origin. Later she was found to have rheumatic heart disease with severe aortic regurgitation & large vegetation was seen attached to the aortic valve. She was treated with rifampicin, clarithromycin, amikacin & levofloxacin based on culture & sensitivity. She succumbed to her illness after development of large cerebral infarction due to embolization of vegetation from aortic valve.

摘要

我们报告了首例风湿性心脏病患者由快速生长的非结核分枝杆菌龟分枝杆菌引起的自发性心内膜炎病例。通过血培养反复分离出快速生长的非典型分枝杆菌，并经反向线探针检测鉴定为龟分枝杆菌，从而确诊。患者表现为不明原因发热。后来发现她患有风湿性心脏病，伴有严重主动脉瓣反流，且在主动脉瓣上可见巨大赘生物。根据培养及药敏结果，给予她利福平、克拉霉素、阿米卡星和左氧氟沙星治疗。她在因主动脉瓣赘生物栓塞导致大面积脑梗死之后，病情恶化并最终死亡。