Min Jung Kee, Kim Jaehong, Woo Je Moon
Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine , Ulsan , Republic of Korea and.
Ocul Immunol Inflamm. 2015 Jun;23(3):205-11. doi: 10.3109/09273948.2014.891755. Epub 2014 Mar 21.
To evaluate pentraxin3 (PTX3) levels in patients with neovascular age-related macular degeneration (N-ARMD) and to investigate its role as a predictive biomarker.
Thirty individuals with N-ARMD and 30 controls without N-ARMD were studied. Plasma concentrations of C-reactive protein (CRP) and PTX3 were measured in frozen samples using an enzyme-linked immunosorbent assay kit.
PTX3 concentration was 1341 ± 625 pg/mL (mean ± standard deviation) in N-ARMD patients, which was significantly higher than in control subjects (887 ± 478, p = 0.003). The mean CRP level was also significantly higher in N-ARMD (2121 ± 2300) than in control (748 ± 618, p = 0.004). Pearson's correlation analysis showed a significant positive correlation between PTX3 and CRP (r = 0.407, p = 0.002).
Our data support the role of chronic inflammation in the development of ARMD. They also show PTX3 may contribute to efforts to understand pathogenesis of N-ARMD.
评估新生血管性年龄相关性黄斑变性（N-ARMD）患者血清中五聚体蛋白3（PTX3）水平，并探讨其作为预测生物标志物的作用。
研究纳入30例N-ARMD患者和30例非N-ARMD对照者。采用酶联免疫吸附测定试剂盒检测冻存样本中C反应蛋白（CRP）和PTX3的血浆浓度。
N-ARMD患者PTX3浓度为1341±625 pg/mL（平均值±标准差），显著高于对照组（887±478，p = 0.003）。N-ARMD患者的平均CRP水平（2121±2300）也显著高于对照组（748±618，p = 0.004）。Pearson相关性分析显示PTX3与CRP之间存在显著正相关（r = 0.407，p = 0.002）。
我们的数据支持慢性炎症在年龄相关性黄斑变性发病中的作用。这些数据还表明PTX3可能有助于理解N-ARMD的发病机制。
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