Page Anne-Laure, Jusot Viviane, Mamaty Abdoul-Aziz, Adamou Lagare, Kaplon Jérôme, Pothier Pierre, Djibo Ali, Manzo Mahamane L, Toure Brahima, Langendorf Céline, Collard Jean-Marc, Grais Rebecca F
Emerg Infect Dis. 2014 Apr;20(4):573-80. doi: 10.3201/eid2004.131328.
Knowledge of rotavirus epidemiology is necessary to make informed decisions about vaccine introduction and to evaluate vaccine impact. During April 2010-March 2012, rotavirus surveillance was conducted among 9,745 children <5 years of age in 14 hospitals/health centers in Niger, where rotavirus vaccine has not been introduced. Study participants had acute watery diarrhea and moderate to severe dehydration, and 20% of the children were enrolled in a nutrition program. Of the 9,745 children, 30.6% were rotavirus positive. Genotyping of a subset of positive samples showed a variety of genotypes during the first year, although G2P[4] predominated. G12 genotypes, including G12P[8], which has emerged as a predominant strain in western Africa, represented >80% of isolates during the second year. Hospitalization and death rates and severe dehydration among rotavirus case-patients did not differ during the 2 years. The emergence of G12P[8] warrants close attention to the characteristics of associated epidemics and possible prevention measures.
了解轮状病毒流行病学对于就疫苗引入做出明智决策以及评估疫苗影响至关重要。在2010年4月至2012年3月期间，在尚未引入轮状病毒疫苗的尼日尔的14家医院/健康中心，对9745名5岁以下儿童进行了轮状病毒监测。研究参与者患有急性水样腹泻和中度至重度脱水，20%的儿童参加了营养项目。在9745名儿童中，30.6%轮状病毒呈阳性。对一部分阳性样本进行基因分型显示，第一年有多种基因型，尽管G2P[4]占主导。包括G12P[8]在内的G12基因型在第二年占分离株的80%以上，G12P[8]已成为西非的主要毒株。两年间，轮状病毒病例患者的住院率、死亡率和严重脱水情况并无差异。G12P[8]的出现值得密切关注相关疫情的特征以及可能的预防措施。
