Petersen I, Hanass Hancock J, Bhana A, Govender K
School of Applied Human Sciences, University of KwaZulu-Natal, South Africa.
Health Economics and HIV/AIDS Research Division (HEARD), University of KwaZulu-Natal, South Africa.
J Affect Disord. 2014 Apr;158:78-84. doi: 10.1016/j.jad.2014.02.013. Epub 2014 Feb 11.
Co-morbid depression in HIV-positive patients on anti-retroviral (ART) treatment poses a public health threat. It compromises treatment adherence and accelerates disease progression. This study aimed to assess the feasibility of a group-based counselling intervention for depressed HIV-positive patients in primary health care (PHC) in South Africa using a task shifting approach.
Using a randomized control design, 76 HIV-positive patients with co-morbid depression were initially recruited. This reduced to 34 in the final cohort. Participants were assessed using the Patient Health Questionnaire (PHQ9), Hopkins Symptom Checklist (HSCL-25) and Multidimensional Scale of Perceived Social Support (MSPSS) at baseline and 3-month follow-up. The intervention was adapted from a local group-based Interpersonal Therapy (IPT) intervention. Process evaluation interviews were held with the HIV counsellors who delivered the intervention and a sub-sample of participants.
Repeated measures ANOVA analysis showed significantly greater improvement on depression scores on the PHQ9 in the intervention group compared to the control group. A significant decline in the mean scores on the HSCL-25 was found for both groups although this was more pronounced for the intervention group. There was no significant improvement in the MSPSS scores.
The small sample size of the final cohort affected the power of the study to detect significant differences between the intervention and control groups on the MSPSS. Longer term impact of the intervention is unknown.
These preliminary findings suggest that group-based counselling for depression in HIV-positive patients can potentially be effectively delivered by appropriately trained and supported lay HIV counsellors. The need for a larger trial is indicated.
接受抗逆转录病毒(ART)治疗的HIV阳性患者合并抑郁症对公共卫生构成威胁。它会影响治疗依从性并加速疾病进展。本研究旨在评估在南非初级卫生保健(PHC)中采用任务转移方法对抑郁的HIV阳性患者进行基于小组的咨询干预的可行性。
采用随机对照设计,最初招募了76名合并抑郁症的HIV阳性患者。最终队列中减少至34名。在基线和3个月随访时,使用患者健康问卷(PHQ9)、霍普金斯症状清单(HSCL-25)和感知社会支持多维量表(MSPSS)对参与者进行评估。干预措施改编自当地基于小组的人际治疗(IPT)干预。对实施干预的HIV咨询师和部分参与者进行了过程评估访谈。
重复测量方差分析显示,与对照组相比,干预组在PHQ9抑郁评分上有显著更大的改善。两组HSCL-25的平均得分均显著下降,尽管干预组更为明显。MSPSS得分没有显著改善。
最终队列的样本量较小,影响了研究检测干预组和对照组在MSPSS上显著差异的能力。干预的长期影响未知。
这些初步结果表明,经过适当培训和支持的非专业HIV咨询师有可能有效地为HIV阳性患者提供基于小组的抑郁症咨询。表明需要进行更大规模的试验。