Lala Anuradha, Desai Akshay S
Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.
Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Heart Fail Clin. 2014 Apr;10(2):353-65. doi: 10.1016/j.hfc.2013.10.002.
Enhanced survival following acute myocardial infarction and the declining prevalence of hypertension and valvular heart disease as contributors to incident heart failure (HF) have fueled the emergence of coronary artery disease (CAD) as the primary risk factor for HF development. Despite the acknowledged role of CAD in the development of HF, the role of coronary revascularization in reducing HF-associated morbidity and mortality remains controversial. The authors review key features of the epidemiology and pathophysiology of CAD in patients with HF as well as the emerging data from recent clinical trials that inform the modern approach to management.
急性心肌梗死后生存率的提高以及高血压和瓣膜性心脏病作为导致心力衰竭（HF）发病率下降的因素，促使冠状动脉疾病（CAD）成为HF发生的主要危险因素。尽管CAD在HF发生中的作用已得到认可，但冠状动脉血运重建在降低HF相关发病率和死亡率方面的作用仍存在争议。作者回顾了HF患者CAD的流行病学和病理生理学的关键特征，以及最近临床试验中为现代管理方法提供依据的新数据。
