Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, Brazil.
Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, Brazil.
Int J Mol Sci. 2018 Jun 20;19(6):1812. doi: 10.3390/ijms19061812.
Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.
炎症是身体应对损伤所引发的主要反应。尽管炎症构成了组织修复的关键组成部分，但众所周知，不受控制或慢性炎症会变得有害，导致进行性组织损伤。过去几年的研究集中在富含具有抗炎和免疫调节特性的多酚的食物上，因为炎症被认为在几种疾病中起核心作用。在这篇综述中，我们讨论了白藜芦醇（研究最广泛的多酚之一）对癌症和神经退行性、呼吸、代谢和心血管疾病的有益作用。我们强调了尽管白藜芦醇的药代动力学不理想，但它如何调节这些疾病的炎症途径，我们确定了评估其临床可行性的未来机会。
