Durko Lukasz, Malecka-Panas Ewa
Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.
Curr Colorectal Cancer Rep. 2014;10(1):45-54. doi: 10.1007/s11888-013-0203-4.
Many studies suggest that Western lifestyle and dietary factors may be responsible for the high incidence of colorectal cancer in industrialized countries. Consumption of high amounts of red and processed meat and low intake of fiber and multiple protective phytochemicals found in fruits, vegetables, and whole grains might be responsible for the high incidence of this neoplasm in the Western world. Additionally, obesity, lack of physical activity, tobacco and alcohol use, sleep deprivation, and other factors have been proven to further increase the risk of colorectal cancer. Identifying and understanding the mechanisms through which they impact colon carcinogenesis is needed for the introduction of protective lifestyle recommendations.
许多研究表明,西方的生活方式和饮食因素可能是工业化国家结直肠癌高发的原因。食用大量红肉和加工肉类,以及水果、蔬菜和全谷物中纤维和多种具有保护作用的植物化学物质摄入不足,可能是西方世界这种肿瘤高发的原因。此外,肥胖、缺乏体育活动、吸烟和饮酒、睡眠不足以及其他因素已被证明会进一步增加患结直肠癌的风险。为了提出具有保护作用的生活方式建议,需要识别并了解它们影响结肠癌发生的机制。