Lee Jae-Seung, Xia Ding, Ge Yulin, Jerschow Alexej, Regatte Ravinder R
Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA; Department of Chemistry, New York University, New York, NY 10003, USA.
Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA.
Neuroimage. 2014 Jul 15;95:22-8. doi: 10.1016/j.neuroimage.2014.03.040. Epub 2014 Mar 21.
The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.
磁共振成像（MRI）中化学交换饱和转移（CEST）和磁化转移（MT）对比技术的发展，使得体内代谢物和生物标志物的检测得到了增强。在脑部MRI中，由于对比机制的频率响应存在重叠，CEST和MT对比的分离一直特别困难。我们在此证明，通过所谓的均匀磁化转移（uMT）技术可以在脑部分离MT和CEST对比，从而为解决该领域长期存在的模糊问题打开了大门。这些方法对于追踪重要的内源性代谢物以及更好地理解神经和神经退行性疾病可能是有用的。展示了来自健康志愿者和多发性硬化症患者白质和灰质区域的示例，这些示例表明脑部的MT效应是不对称的，而uMT方法可以使其变得均匀。
