年龄相关性黄斑变性是一种微血管疾病吗？
Is age-related macular degeneration a microvascular disease?
机构信息
Department of Ophthalmology and Visual Sciences, The University of Lowa, 52242, Lowa City, IA, USA,
出版信息
Adv Exp Med Biol. 2014;801:283-9. doi: 10.1007/978-1-4614-3209-8_36.
Abstract
Age-related macular degeneration (AMD) is a common, degenerative disease of the central retina affecting millions of elderly in the USA alone and many more worldwide. A better understanding of the pathophysiology of AMD will be essential for developing new treatments. In this review, we discuss the potential impact of complement complex deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris loss and drusen formation. We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies.
摘要
年龄相关性黄斑变性（AMD）是一种常见的、退行性的中心视网膜疾病，仅在美国就有数百万老年人受到影响，全球范围内的患者更是不计其数。更好地了解 AMD 的病理生理学对于开发新的治疗方法至关重要。在这篇综述中，我们讨论了补体复合物在衰老眼中脉络膜毛细血管沉积的潜在影响，以及脉络膜毛细血管丧失与玻璃膜疣形成之间的关系。我们进一步提出了一个整合 AMD 遗传和解剖学发现的模型，并提出了这些发现对未来治疗的意义。
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本文引用的文献
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2
Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.遗传视角下的年龄相关性黄斑变性：争议解决风险、因果关系和治疗学。
Mol Aspects Med. 2012 Aug;33(4):467-86. doi: 10.1016/j.mam.2012.04.004. Epub 2012 Apr 27.
3
Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.了解年龄相关性黄斑变性（AMD）：光感受器/视网膜色素上皮/脉络膜/Bruch 膜/脉络膜毛细血管复合体之间的关系。
Mol Aspects Med. 2012 Aug;33(4):295-317. doi: 10.1016/j.mam.2012.04.005. Epub 2012 Apr 21.
4
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Invest Ophthalmol Vis Sci. 2012 Feb 27;53(2):1041-7. doi: 10.1167/iovs.11-8531. Print 2012 Feb.
5
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Ophthalmology. 2012 Feb;119(2):339-46. doi: 10.1016/j.ophtha.2011.07.056. Epub 2011 Nov 30.
6
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7
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Retina. 2012 Jan;32(1):25-31. doi: 10.1097/IAE.0b013e3182150483.
8
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J Transl Med. 2011 Jul 15;9:1-12. doi: 10.1186/1479-5876-9-111.
9
Elevated membrane attack complex in human choroid with high risk complement factor H genotypes.人脉络膜中膜攻击复合物升高与高风险补体因子 H 基因型有关。
Exp Eye Res. 2011 Oct;93(4):565-7. doi: 10.1016/j.exer.2011.06.015. Epub 2011 Jun 26.
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Br J Ophthalmol. 2011 Sep;95(9):1323-30. doi: 10.1136/bjo.2010.199216. Epub 2011 Jun 1.
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